TriLink | Radioactive Oligonucleotides

Isotopic Sulfur (35S)
Tritium (3H)
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Pharmacokinetic Studies Article
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Radioactive Oligonucleotides Radioactively labeled oligonucleotides play a very important role in the development of biomolecules as drugs. Compounds carrying a radioactive tag can be readily tracked in vitro and in vivo. For in vivo pharmacodynamic research, a radioactively tagged compound is superior to all other available forms of detection, and thus the FDA often requires studies involving radioactively labeled biomolecules for the IND (investigative new drug) filing in the drug approval process.

" I can certainly second that TriLink supplies tritiated oligonucleotides which are difficult to produce in high quality and in a timely fashion. Also I very much like the excellent communication with the project team."
- Dr. Stefan Vonhoff, Vice President CMC, NOXXON Pharma AG

TriLink has considerable experience in preparing radioactively labeled oligonucleotides specifically for pre-clinical trials. We offer sulfur (35S) and tritium (3H) labeling of phosphodiester and phosphorothioate oligonucleotides. Our compounds are prepared by hand and the radiolabel is incorporated during synthesis of the oligonucleotide to ensure isotope placement, stability, experimental control and quality. Our radiolabeled compounds come with a purity guarantee of at least 90% full length product. Purity up to 98% is available, please inquire for pricing and processing details.

In addition to offering radiolabeled oligonucleotides, we are also available to consult with you on the development of your specific pharmacokinetic experiments. Please contact us to discuss your development needs.