RNA Oligonucleotides TriLink is an industry leader in manufacturing high quality modified RNA oligonucleotides for research, diagnostics, OEM and therapeutics. We specialize in challenging constructs, such as siRNA, microRNA and aptamers, as well as scaling up to mid-scale quantities (50 mg - 10 g). Visit OligoBuilder® to price and order your RNA oligonucleotide.
Over the last two decades, there has been significant progress in the development of oligonucleotides as therapeutics. RNA and DNA oligonucleotides have been used as antisense inhibitors, aptamers, CpG immunostimulatory molecules, molecular decoys and as RNA interference (RNAi) triggers. Antisense therapeutics are currently experiencing a renaissance, with very promising results in preclinical studies in non-human primates and in human clinical trials.
RNAi is a phenomenon in which the introduction of double-stranded RNA into a cell results in sequence-specific gene silencing. RNAi is a powerful research tool and a promising new class of potential therapeutics. Investigations into the mechanisms of RNAi have led to the discovery of microRNAs, which are thought to regulate about half of all genes. Oligonucleotide based microRNA mimics and inhibitors are exciting new therapeutic research tools. Aptamers are also showing promise as therapeutics in animal models and are likely to be useful in the field of proteomics.
TriLink is a key supplier of RNA and DNA oligonucleotides for pre-clinical research. We specialize in highly modified oligonucleotides, including RNA and derivatives such as 2' O-Methyl RNA, 2' Fluoro RNA, as well as thioated versions and conjugation to molecules such as PEG and cholesterol.
Every oligonucleotide manufactured at TriLink undergoes quality control analysis by PAGE, HPLC and/or MS. Further service options are available including additional purifications and analyses, annealing, aliquotting and large batch synthesis up to 10 grams final product. We are here to support your RNA research through our expertise in high quality nucleic acid synthesis and modification and excellent technical support.
