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2'-Fluoro-2'-deoxyuridine-5'-Triphosphate - (N-1010)

In stock
Product SKU Unit Size Price Qty
N-1010-1 1 µmole
N-1010-5 5 µmole
N-1010-10 10 µmole
N-1010-100 10 x 10 µmole
2'-Fluoro NTPs are being utilized in an increasing number of applications in research and new drug development. 2'-Fluoro-dUTP is incorporated in both DNA and RNA constructs to improve in vivo stability. Both 2' Fluoro dU and dC are used in the design and synthesis of aptamers, antagomirs and siRNA, because they impart increased target affinity and resistance to endonuclease degradation, while reducing immune response. A key technique utilized in aptamer development using 2'-Fluoro-dUTP is SELEX (Systematic Evolution of Ligands by Exponential Enrichment). The SELEX process allows for the simultaneous screening of 1 x 1015 different oligonucleotides against a target of interest, such as a protein. The main goal of SELEX is to identify a small subset of aptamers from the original library that bind to the target of interest. Learn more in the technical article: An Overview of the SELEX Process. "TriLink offers not just better pricing but specialized services at large scale and functional, quality 2’-Fluoro-dCTP and 2’-Fluoro-dUTP. TriLink’s technical customer support was knowledgeable and gave me confidence about the products." Sriramchandra Mangipudi Bioengineer University of Washington, Seattle
Product details
Catalog No N-1010
Purity ≥95% by AX-HPLC
Extinction Coefficient 10,100 Lmol-1cm-1 at 262 nm
Molecular Formula C9H14N2O14P3F (free acid)
Molecular Weight 486.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 2'-F-dUTP
Application Aptamers
Backbone 5'-Triphosphate
Base Analog(s) Uridine
Sugar Type(s) 2'-Fluoro
Nucleotide Category Sugar Modified
Technical documents

N-1010 Safety Data Sheet

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Intellectual property

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.

TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.

  1. Du, Mei; Ulrich, Henning; Zhao, Xiurong; Aronowski, Jaroslaw; Jayaraman, Vasanthi . Water soluble RNA based antagonist of AMPA receptors.
  2. Madsen, Jeppe B.; Dupont, Daniel M.; Andersen, Thomas B.; Nielsen, Anne F.; Sang, Lu; Brix, Ditte M.; Jensen, Jan K.; Broos, Thomas; Hendrickx, Maarten L. V.; Christensen, Anni; Kjems, Jørgen; Andreasen, Peter A. . RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1.
  3. Joubert, Marisa K.; Kinsley, Nichole; Capovilla, Alexio; Sewell, B. Trevor; Jaffer, Mohamed A.; Khati, Makobetsa . A Modeled Structure of an Aptamer-gp120 Complex Provides Insight into the Mechanism of HIV-1 Neutralization
  4. Nicol, Clare; Bunka, David H. J.; Blair, G. Eric; Stonehouse, Nicola J. . Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein.
  5. Shu, Dan; Shu, Yi; Haque, Farzin; Abdelmawla, Sherine; Guo, Peixuan . Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics.
  6. Liu, Jing; Guo, Songchuan; Cinier, Mathieu; Shlyakhtenko, Luda S.; Shu, Yi; Chen, Chaoping; Shen, Guanxin; Guo, Peixuan . Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging.
  7. Kanwar, Jagat R.; Roy, Kislay; Kanwar, Rupinder K. . Chimeric aptamers in cancer cell-targeted drug delivery.
  8. Lauridsen, Lasse H.; Rothnagel, Joseph A.; Veedu, Rakesh N. . Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers.
  9. Bompiani, K. M.; Monroe, D. M.; Church, F. C.; Sullenger, B. A. . A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.
  10. Ono, T.; Scalf, M.; Smith, L. M. . 2'-Fluoro modified nucleic acids: polymerase-directed synthesis, properties and stability to analysis by matrix-assisted laser desorption/ionization mass spectrometry.
  11. Thiel, Kristina W.; Hernandez, Luiza I.; Dassie, Justin P.; Thiel, William H.; Liu, Xiuying; Stockdale, Katie R.; Rothman, Alissa M.; Hernandez, Frank J.; McNamara, James O. 2nd; Giangrande, Paloma H. . Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers.
  12. Botkjaer, Kenneth A.; Deryugina, Elena I.; Dupont, Daniel M.; Gårdsvoll, Henrik; Bekes, Erin M.; Thuesen, Cathrine K.; Chen, Zhuo; Ploug, Michael; Quigley, James P.; Andreasen, Peter A. . Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism.
  13. Green, Nathaniel M.; Moody, Krishna-Sulayman; Debatis, Michelle; Marshak-Rothstein, Ann . Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.
  14. Thiel, William H.; Bair, Thomas; Peek, Andrew S.; Liu, Xiuying; Dassie, Justin; Stockdale, Katie R.; Behlke, Mark A.; Miller, Francis J. Jr; Giangrande, Paloma H. . Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.
  15. Reif, Randall; Haque, Farzin; Guo, Peixuan . Fluorogenic RNA nanoparticles for monitoring RNA folding and degradation in real time in living cells.
  16. Cozens, Christopher; Pinheiro, Vitor B.; Vaisman, Alexandra; Woodgate, Roger; Holliger, Philipp . A short adaptive path from DNA to RNA polymerases.
  17. Dupont, Daniel M.; Larsen, Niels; Jensen, Jan K.; Andreasen, Peter A.; Kjems, Jørgen . Characterisation of aptamer-target interactions by branched selection and high-throughput sequencing of SELEX pools.
  18. Dupont, Daniel M.; Bjerregaard, Nils; Verpaalen, Ben; Andreasen, Peter A.; Jensen, Jan K. . Building a Molecular Trap for a Serine Protease from Aptamer and Peptide Modules.
  19. Szameit, Kristina; Berg, Katharina; Kruspe, Sven; Valentini, Erica; Magbanua, Eileen; Kwiatkowski, Marcel; Chauvot de Beauchêne, Isaure; Krichel, Boris; Schamoni, Kira; Uetrecht, Charlotte; Svergun, Dmitri I.; Schlüter, Hartmut; Zacharias, Martin; Hahn, Ulrich . Structure and target interaction of a G-quadruplex RNA-aptamer.
  20. Xiao, Shou-Jun . Assembling RNA Nanoparticles.
  21. Quang, Nam Nguyen; Miodek, Anna; Cibiel, Agnes; Ducongé, Frédéric . Selection of Aptamers Against Whole Living Cells: From Cell-SELEX to Identification of Biomarkers.
  22. Haque, Farzin; Xu, Congcong; Jasinski, Daniel L.; Li, Hui; Guo, Peixuan . Using Planar Phi29 pRNA Three-Way Junction to Control Size and Shape of RNA Nanoparticles for Biodistribution Profiling in Mice.
  23. Wang, Hanlu; Zhang, Yibang; Yang, Haiping; Qin, Meng; Ding, Xinxin; Liu, Rihe; Jiang, Yongping . In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library.
  24. Yu, Xiaolin; Ghamande, Sharad; Liu, Haitao; Xue, Lu; Zhao, Shuhua; Tan, Wenxi; Zhao, Lijing; Tang, Shou-Ching; Wu, Daqing; Korkaya, Hasan; Maihle, Nita J.; Liu, Hong Yan . Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2(+) Breast Cancer.
  25. Porciani, David; Cardwell, Leah N.; Tawiah, Kwaku D.; Alam, Khalid K.; Lange, Margaret J.; Daniels, Mark A.; Burke, Donald H. . Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines.
  26. Xue, Lu; Maihle, Nita J.; Yu, Xiaolin; Tang, Shou-Ching; Liu, Hong Yan . Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth.
  27. Szameit, K;Berg, K;Kruspe, S;Valentini, E;Magbanua, E;Kwiatkowski, M;Chauvot de Beauch . Structure and target interaction of a G-quadruplex RNA-aptamer
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