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4-Thiouridine-5'-Triphosphate - (N-1025)

4-Thio-UTP, Thio UTP
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4-Thiouridine is useful for UV photocrosslinking studies to identify sites of ribonucleoprotein-RNA interactions and to crosslink sites containing RNA secondary and tertiary structure. Incorporation of 4-Thiouridine allows for specific crosslinking at longer wavelengths, typically between 320 and 360 nm, which results in minimal RNA damage compared to standard shortwave UV light. 4-Thiouridine-5'-Triphosphate can also be incorporated into RNA to allow specific and efficient tagging of the modified base with sulfur-reactive methylthiosulfonate-activated labels. "The 4-Thio-UTP I had ordered from TriLink worked like a charm." Vaishnavi Rajagopal Post-doctoral Fellow Johns Hopkins University School of Medicine blank "We were impressed with the timing and the quality of the 4-Thio-UTP that we ordered. Obviously it is of utmost importance to our research that we are able to rely on companies such as TriLink to provide quality products when we require them." Christine Woltjen Research Associate Ohio State University
Product details
Catalog No N-1025
Purity ≥90% by AX-HPLC
Extinction Coefficient 16,526 Lmol-1cm-1 at 331 nm
Molecular Formula C9H15N2O14P3S (free acid)
Molecular Weight 500.20 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 4-Thio-UTP, Thio UTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Uridine
Sugar Type(s) RNA
Nucleotide Category Base Modified RNA
Technical documents

N-1025 Safety Data Sheet

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Intellectual property

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.

TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.

  1. Kashkina, Ekaterina; Anikin, Michael; Tahirov, Tahir H.; Kochetkov, Sergei N.; Vassylyev, Dmitry G.; Temiakov, Dmitry . Elongation complexes of Thermus thermophilus RNA polymerase that possess distinct translocation conformations.
  2. Ma, Kaiyu; Temiakov, Dmitri; Jiang, Manli; Anikin, Michael; McAllister, William T. . Major conformational changes occur during the transition from an initiation complex to an elongation complex by T7 RNA polymerase.
  3. Park, Euisun; Baron, Rose; Landgraf, Ralf . Higher-Order Association States of Cellular ERBB3 Probed with Photo-Cross-Linkable Aptamers†
  4. Sokoloski, Joshua E.; Dombrowski, Sarah E.; Bevilacqua, Philip C. . Thermodynamics of ligand binding to a heterogeneous RNA population in the malachite green aptamer.
  5. Kanwar, Jagat R.; Roy, Kislay; Kanwar, Rupinder K. . Chimeric aptamers in cancer cell-targeted drug delivery.
  6. Zheng, Ke-wei; Wu, Ren-yi; He, Yi-de; Xiao, Shan; Zhang, Jia-yu; Liu, Jia-quan; Hao, Yu-hua; Tan, Zheng . A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site.
  7. Heyn, Patricia; Kircher, Martin; Dahl, Andreas; Kelso, Janet; Tomancak, Pavel; Kalinka, Alex T.; Neugebauer, Karla M. . The earliest transcribed zygotic genes are short, newly evolved, and different across species.
  8. Duffy, Erin E.; Simon, Matthew D. . Enriching s(4) U-RNA Using Methane Thiosulfonate (MTS) Chemistry.
  9. Wang, Xueyin; Goodrich, Karen J.; Gooding, Anne R.; Naeem, Haroon; Archer, Stuart; Paucek, Richard D.; Youmans, Daniel T.; Cech, Thomas R.; Davidovich, Chen . Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.
  10. Schofield, Jeremy A.; Duffy, Erin E.; Kiefer, Lea; Sullivan, Meaghan C.; Simon, Matthew D. . TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding.
  11. Hallé, François; Fin, Andrea; Rovira, Alexander R.; Tor, Yitzhak . Emissive Synthetic Cofactors: Enzymatic Interconversions of (tz) A Analogues of ATP, NAD(+) , NADH, NADP(+) , and NADPH.
  12. Shubham, Shambhavi; Hoinka, Jan; Banerjee, Soma; Swanson, Emma; Dillard, Jacob A.; Lennemann, Nicholas J.; Przytycka, Teresa M.; Maury, Wendy; Nilsen-Hamilton, Marit . A 2'FY-RNA Motif Defines an Aptamer for Ebolavirus Secreted Protein.
  13. Barbieri, E;Hill, C;Quesnel-Valli . Rapid and Scalable Profiling of Nascent RNA with fastGRO
  14. Fujiwara, R; . Structral and Biochemical Insights Into the Transition from Transcription Initiation to Elongation
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