5-Formyl-2’-deoxycytidine-5’-Triphosphate - (N-2064)
5-Formyl-dCTP, 5-fdCTP,5-CHO-dCTP, 5-Fo-dCTP
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N-2064
Description
5-formyl-dC is mutagenic and has been shown to induce the 5-fC →T transition mutation as well as 5-fC →A and 5-fC →G transversion mutations during DNA synthesis, particularly in methylated CpG regions (Kamiya et al., Münzel et al.)
Product details
Catalog No | N-2064 |
---|---|
Purity | ≥90% by AX-HPLC |
Extinction Coefficient | 11,000 Lmol-1cm-1 at 283 nm |
Molecular Formula | C10H16N3O14P3 (free acid) |
Molecular Weight | 495.10 g/mole (free acid) |
Salt Form | Li+ |
Concentration | 100 mM |
Buffer | H2O |
Recommended Storage | -20°C or below |
Other Name(s) | 5-Formyl-dCTP, 5-fdCTP,5-CHO-dCTP, 5-Fo-dCTP |
Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
Backbone | 5'-Triphosphate |
Base Analog(s) | Cytidine |
Sugar Type(s) | DNA |
Nucleotide Category | Base Modified DNA |
Technical documents
N-2064 Safety Data Sheet
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Certificate of analysis
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Intellectual property
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References
- Patiño-Parrado, Iris; Gómez-Jiménez, Álvaro; López-Sánchez, Noelia; Frade, José M. . Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting.
- Wang, Shao-Ru; Song, Yan-Yan; Wei, Lai; Liu, Chao-Xing; Fu, Bo-Shi; Wang, Jia-Qi; Yang, Xi-Ran; Liu, Yi-Nong; Liu, Si-Min; Tian, Tian; Zhou, Xiang . Cucurbit[7]uril-Driven Host-Guest Chemistry for Reversible Intervention of
- Lei, Z;Meng, H;Lv, Z;Liu, M;Zhao, H;Wu, H;Zhang, X;Liu, L;Zhuang, Y;Yin, K;Yan, Y;Yi, C; . Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors