SoluLINK® bioconjugation technology is ideal for linking peptides to oligonucleotides, proteins, and surfaces to improve purification, detection, delivery, and targeting. 6-BOC-HNA is used to incorporate BOC-protected HyNic (6-hydrazinonicotinamide) molecules onto peptides during solid- or solution-phase peptide synthesis. This reagent is also useful for small molecule, surface, and polymer activation with HyNic where acid-labile protection is required. It can be coupled to the N-terminal peptide amino group as the last step in the synthesis prior to cleavage, or coupled to the side chain of a lysine residue introduced using an orthogonally protected derivative such as Lys(ivDde) or Lys(Mtt). The linker requires activation with a coupling agent, such as a carbodiimide, for incorporation during peptide synthesis. HyNic-modified peptides and other molecules are readily conjugated to 4FB-modified biomolecules.
|Application||Antibody Labeling, Antisense/RNAi, Aptamers, Immunotherapeutics, Therapeutics and Drug Discovery|
|Other Name(s)||6-BOC-hydrazinonicotinic acid|
SoluLINK Bioconjugation For Research Use Only. Not for use in diagnostic procedures. For additional licensing restrictions, please see the license agreement at trilinkbiotech.com/solulink-research-license.
Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission of Seller. No license under any patent or other intellectual property right of Seller or its licensors is granted or implied by the purchase unless otherwise provided in writing.
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