8-5'(5'S)-Cyclo-2'-deoxyadenosine

8-5'-Cyclo-dA
-->

This modification is available as part of a custom oligonucleotide configuration. Please use OLIGObuilder™ to generate pricing and order or contact us to speak with a customer service representative.

Ready to order your oligonucleotide?

Inquiry Form

Product Details

OLIGObuilder Code {85Cyc-dA}
Other Name(s) 8-5'-Cyclo-dA
Base Analog(s) Adenosine
Oligo Modification Type DNA Purines (A or G) Analog


References

Evans, Mark D.; Dizdaroglu, Miral; Cooke, Marcus S. . Oxidative DNA damage and disease: induction, repair and significance.

Jaruga, Pawel; Dizdaroglu, Miral . 8,5'-Cyclopurine-2'-deoxynucleosides in DNA: mechanisms of formation, measurement, repair and biological effects.

Brooks, P. J.; Wise, D. S.; Berry, D. A.; Kosmoski, J. V.; Smerdon, M. J.; Somers, R. L.; Mackie, H.; Spoonde, A. Y.; Ackerman, E. J.; Coleman, K.; Tarone, R. E.; Robbins, J. H. . The oxidative DNA lesion 8,5'-(S)-cyclo-2'-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells.

Kuraoka, I.; Bender, C.; Romieu, A.; Cadet, J.; Wood, R. D.; Lindahl, T. . Removal of oxygen free-radical-induced 5',8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells.

Marietta, Cheryl; Brooks, Philip J. . Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells.

Romieu, Anthony; Gasparutto, Didier; Molko, Didier; Cadet, Jean . Site-Specific Introduction of (5`S)-5`,8-Cyclo-2`-deoxyadenosine into Oligodeoxyribonucleotides

Romieu, Anthony; Gasparutto, Didier; Cadet, Jean . Synthesis and Characterization of Oligonucleotides Containing 5`,8-Cyclopurine 2`-Deoxyribonucleosides: (5`R)-5`,8-Cyclo-2`-deoxyadenosine, (5`S)-5`,8-Cyclo-2`-deoxyguanosine, and (5`R)-5`,8-Cyclo-2`-deoxyguanosine

Jaruga, Pawel; Theruvathu, Jacob; Dizdaroglu, Miral; Brooks, Philip J. . Complete release of (5'S)-8,5'-cyclo-2'-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions.