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Epigenetics/DNA Damage

Epigenetics is the study of heritable changes in gene expression that do not involve modifications of the genetic code itself. Such changes have been implicated in the cellular pathways underlying memory formation, X chromosome activation, cellular differentiation, and cancer.

A primary source of epigenetic effects is DNA methylation. Cells use DNA methylation to control gene expression. For example, methylation of cytidine to 5-methyl-dC within CpG sites is associated with transcriptionally silent DNA regions. New base modifications involved in epigenetic pathways are continually being discovered, such as 5-hydroxymethyl-dU, 5-hydroxymethyl-dC, and 5-formyl-dC, which were recently found to be key players in the epigenetic pathway for 5-methyl-dC. DNA damage, chromatin remodeling, histone modification, and other mechanisms involving non-coding RNA have also been linked to epigenetic modifications.

To support research in epigenetics, TriLink offers epigentic products and custom services. The only source of many of the newly-discovered and difficult-to-manufacture base modifications, TriLink remains at the forefront of product manufacturing for epigenetic research.

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Oligo Modifications