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Nucleic Acids

Cloaking mRNA to Control Stability and Translation in Cells
Perspectives on In Vitro Transcription (IVT) mRNA Sequence Optimization
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Perspectives on In Vitro Transcription (IVT) mRNA Sequence Optimization

This blog provides some perspective on published strategies for this type of sequence optimization, which is alternatively referred to sequence engineering. This topic has been trending upwards in recent years, as indicated by the linear forecast dashed line shown in this chart reports found by word searching the NIH PubMed database for 2013 – 2020.