Modified Oligonucleotide Publications

Hot start PCR with heat-activatable primers: a novel approach for improved PCR performance.

Lebedev AV, Paul N, Yee J, Timoshchuk VA, Shum J, Miyagi K, Kellum J, Hogrefe RI, Zon G.

Nucleic Acids Res. 2008 Nov;36(20):e131. doi: 10.1093/nar/gkn575. Epub 2008 Sep 16.

Comparison of binding of N3'-->P5' phosphoramidate and phosphorothioate oligonucleotides to cell surface proteins of cultured cells.

Hawley P, Nelson JS, Fearon KL, Zon G, Gibson I.

Antisense Nucleic Acid Drug Dev. 1999 Feb;9(1):61-9.

The interaction of intercalators and groove-binding agents with DNA triple-helical structures: the influence of ligand structure, DNA backbone modifications and sequence.

Wilson WD, Mizan S, Tanious FA, Yao S, Zon G.

J Mol Recognit. 1994 Jun;7(2):89-98. Review.

Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET).

Sixou S, Szoka FC Jr, Green GA, Giusti B, Zon G, Chin DJ.

Nucleic Acids Res. 1994 Feb 25;22(4):662-8.

Stabilities of duplexes and triplexes of dA19 + dT19 with alternating methylphosphonate and phosphodiester linkages.

Kibler-Herzog L, Zon G, Whittier G, Mizan S, Wilson WD.

Anticancer Drug Des. 1993 Feb;8(1):65-79.

Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers.

Kibler-Herzog L, Zon G, Uznanski B, Whittier G, Wilson WD.

Nucleic Acids Res. 1991 Jun 11;19(11):2979-86.

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.

Chin DJ, Green GA, Zon G, Szoka FC Jr, Straubinger RM.

New Biol. 1990 Dec;2(12):1091-100.

Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes.

Kibler-Herzog L, Kell B, Zon G, Shinozuka K, Mizan S, Wilson WD.

Nucleic Acids Res. 1990 Jun 25;18(12):3545-55.

Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC>


Bower M, Summers MF, Powell C, Shinozuka K, Regan JB, Zon G, Wilson WD.

Nucleic Acids Res. 1987 Jun 25;15(12):4915-30.

Synthesis and characterization of oligodeoxyribonucleotides containing terminal phosphates. NMR, UV spectroscopic and thermodynamic analysis of duplex formation of [d(pGGAATTCC)>

2, [d(GGAATTCCp)>

2 and [d(pGGAATTCCp)>


Bower M, Summers MF, Kell B, Hoskins J, Zon G, Wilson WD.

Nucleic Acids Res. 1987 Apr 24;15(8):3531-47.

NMR studies of backbone-alkylated DNA: duplex stability, absolute stereochemistry, and chemical shift anomalies of prototypal isopropyl phosphotriester modified octanucleotides, (Rp,Rp)- and (Sp,Sp)-(d-[GGA(iPr)ATTCC>

)2 and -(d-[GGAA(iPr)TTCC>


Lawrence DP, Chen WQ, Zon G, Stec WJ, Uznanski B, Broido MS.

J Biomol Struct Dyn. 1987 Apr;4(5):757-83.

Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)>

2, derived from diastereomeric O-ethyl phosphorothioates.

LaPlanche LA, James TL, Powell C, Wilson WD, Uznanski B, Stec WJ, Summers MF, Zon G.

Nucleic Acids Res. 1986 Nov 25;14(22):9081-93.

Alkyl phosphotriester modified oligodeoxyribonucleotides. VI. NMR and UV spectroscopic studies of ethyl phosphotriester (Et) modified Rp-Rp and Sp-Sp duplexes, (d[GGAA(Et)TTCC>


Summers MF, Powell C, Egan W, Byrd RA, Wilson WD, Zon G.

Nucleic Acids Res. 1986 Sep 25;14(18):7421-36.

Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC>

. A synthetic approach to regio- and stereospecific ethylation-interference studies.

Gallo KA, Shao KL, Phillips LR, Regan JB, Koziolkiewicz M, Uznanski B, Stec WJ, Zon G.

Nucleic Acids Res. 1986 Sep 25;14(18):7405-20.

Reversed-phase high-performance liquid chromatographic separation of diastereomeric phosphorothioate analogues of oligodeoxyribonucleotides and other backbone-modified congeners of DNA.

Stec WJ, Zon G, Uznanski B.

J Chromatogr. 1985 Jun 19;326:263-80.

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