Contact Us

Posts tagged 'Nanoparticles'

Universal Flu Vaccine—Multivalent mRNA Vaccine for All Known Seasonal Influenza Viruses
mRNA Vaccine for Protection Against Peanut Allergy Anaphylaxis
mRNA Vaccines for Rapid Response to Biological Threats
mRNA Therapeutics for Neurological Diseases and Pain
Applying CleanCap® mRNA: 4 Example Studies
Loading...
664 view(s)

Applying CleanCap® mRNA: 4 Example Studies

Historically, reporter genes have been delivered as DNA plasmids for transcription into mRNA before translation into a reporter protein. In biological systems, ideal reporter proteins generate highly sensitive signals that are easily measurable. Thus, they are often photoluminescent (e.g., GFP) or chemiluminescent (e.g., luciferase).

Four Pillars for Successful Self-Amplifying RNA Vaccines…
Loading...
2394 view(s)

Four Pillars for Successful Self-Amplifying RNA Vaccines…

The current universe of vaccines can be divided into two main categories, conventional vaccines and nucleic acid vaccines (Blakney et al.). Conventional vaccines are based on a protein adjuvant, and nucleic acid vaccines can be based on DNA or RNA. For this blog, we will focus on nucleic acid vaccines based on RNA structures and, in particular, self-amplifying RNA vaccines (Figure 1).

CleanCap® IVT Cas9 mRNA in Micelles Used for Genome Editing in Mouse Brain for the First Time
Loading...
301 view(s)

CleanCap® IVT Cas9 mRNA in Micelles Used for Genome Editing in Mouse Brain for the First Time

CRISPR-based genome editing tools show tremendous potential as therapeutic agents for the treatment of genetic diseases and viral infections, as discussed in previous Zone blogs and the June 2021 TriLink Research Spotlight titled, A Novel Base-Editing Strategy Promises to Treat Sickle Cell Disease. Nevertheless, safe and efficient delivery of CRISPR tools to target tissues continues to attract growing attention (see Chart). A wide variety of technical approaches are being explored, the main one being the formulation of nano-sized particles loaded with different types of CRISPR-related cargo.