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You are at : All > Nucleotides > Nucleotides by Structural Class > Sugar Modified Nucleoside Triphosphates

Sugar Modified Nucleoside Triphosphates

The most common application of sugar modified DNA triphosphates is chain termination.TriLink offers the widest selection of 2′ modified 2′,3′ dideoxynucleoside triphosphates available, from post synthetically modifiable 2′ amino ddNTP for standard conjugations to 2′ azido ddNTP for click chemistry.
 
Sugar modified RNA nucleotides, on the other hand are used to impart nuclease resistance to RNA. The molecule retains the A-form duplex structure characteristic of RNA, but modification of the 2′ hydroxyl, which is often crucial to either the binding or the activity of the enzyme, will offer a level of protection against nuclease degradation and other enzymatic events. The most popular sugar modified NTPs are the 2′ O-methyl modified NTPs, followed by the 2′ fluoro modified NTPs. Both of these modifications will increase the melting temperature of a duplex by 1 to 3°C per insertion depending on which modification is used, the base and position.

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2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate

2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate

2'-F-dATP


2'-Fluoro-2'-deoxycytidine-5'-Triphosphate

2'-Fluoro-2'-deoxycytidine-5'-Triphosphate

 2'-F-dCTP


2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate

2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate

2'-F-dGTP


2'-Fluoro-2'-deoxyuridine-5'-Triphosphate

2'-Fluoro-2'-deoxyuridine-5'-Triphosphate

2'-F-dUTP


2'-O-Methyladenosine-5'-Triphosphate

2'-O-Methyladenosine-5'-Triphosphate

2'-O-Methyl-ATP


2'-O-Methylcytidine-5'-Triphosphate

2'-O-Methylcytidine-5'-Triphosphate

2'-O-Methyl-CTP, 2'OMe-CTP


2'-O-Methylguanosine-5'-Triphosphate

2'-O-Methylguanosine-5'-Triphosphate

2'-O-Methyl-GTP


2'-O-Methyluridine-5'-Triphosphate

2'-O-Methyluridine-5'-Triphosphate

2'-O-Methyl-UTP, 2'OMe-UTP


2'-O-Methylinosine-5'-Triphosphate

2'-O-Methylinosine-5'-Triphosphate

2'-O-Methyl-ITP


2'-Amino-2'-deoxycytidine-5'-Triphosphate

2'-Amino-2'-deoxycytidine-5'-Triphosphate

2'-Amino-dCTP


2'-Amino-2'-deoxyuridine-5'-Triphosphate

2'-Amino-2'-deoxyuridine-5'-Triphosphate

2'Amino-dUTP


2'-Azido-2'-deoxycytidine-5'-Triphosphate

2'-Azido-2'-deoxycytidine-5'-Triphosphate

2'-Azido-dCTP


2'-Azido-2'-deoxyuridine-5'-Triphosphate

2'-Azido-2'-deoxyuridine-5'-Triphosphate

2'-Azido-dUTP


Aracytidine-5'-Triphosphate

Aracytidine-5'-Triphosphate

1-β-D-arabinofuranosylcytosine TP, Ara-CTP


Arauridine-5'-Triphosphate

Arauridine-5'-Triphosphate

Ara-UTP


2'-O-Methyl-2-aminoadenosine-5'-Triphosphate

2'-O-Methyl-2-aminoadenosine-5'-Triphosphate

2'-O-Methyl-2-Amino-ATP, 2'-O-Methyl-2,6-Diaminopurine-ribose-5'-Triphosphate, 2'-O-Methyl-DAP-rTP


2'-O-Methylpseudouridine-5'-Triphosphate

2'-O-Methylpseudouridine-5'-Triphosphate

2'-O-Methylpseudo-UTP



2'-O-Methyl-5-methyluridine-5'-Triphosphate

2'-O-Methyl-5-methyluridine-5'-Triphosphate

2'-O-Methyl-5-methyl-UTP


2'-Azido-2'-deoxyadenosine-5'-Triphosphate

2'-Azido-2'-deoxyadenosine-5'-Triphosphate

2'-Azido-dATP




2'-Amino-2'-deoxyadenosine-5'-Triphosphate

2'-Amino-2'-deoxyadenosine-5'-Triphosphate

2'-Amino-dATP




Araadenosine-5'-Triphosphate

Araadenosine-5'-Triphosphate

Ara-ATP, Vidarabine triphosphate


2'-Fluoro-thymidine-5'-Triphosphate

2'-Fluoro-thymidine-5'-Triphosphate

2'-F-dTTP




3'-O-Methyladenosine-5'-Triphosphate

3'-O-Methyladenosine-5'-Triphosphate

3'-O-Methyl-ATP


3'-O-Methylcytidine-5'-Triphosphate

3'-O-Methylcytidine-5'-Triphosphate

3'-O-Methyl-CTP


3'-O-Methylguanosine-5'-Triphosphate

3'-O-Methylguanosine-5'-Triphosphate

3'-O-Methyl-GTP


3'-O-Methyluridine-5'-Triphosphate

3'-O-Methyluridine-5'-Triphosphate

3'-O-Methyl-UTP




2'-Azido-2'-deoxyguanosine-5'-Triphosphate

2'-Azido-2'-deoxyguanosine-5'-Triphosphate

2'-Azido-dGTP




2'-Amino-2'-deoxyguanosine-5'-Triphosphate

2'-Amino-2'-deoxyguanosine-5'-Triphosphate

2'-Amino-dGTP




Araguanosine-5'-Triphosphate

Araguanosine-5'-Triphosphate

Ara-GTP


N<sup>1</sup>-Methyl-2'-O-Methylpseudouridine-5'-Triphosphate

N1-Methyl-2'-O-Methylpseudouridine-5'-Triphosphate

N1-Methyl-2'-O-Methylpseudo-UTP, N1,2'-O-Dimethylpseudo-UTP


2'-O-Methyl-N<sup>6</sup>-Methyladenosine-5'-Triphosphate

2'-O-Methyl-N6-Methyladenosine-5'-Triphosphate

2'-O-Methyl-N6-Methyl-ATP, 2'-O-Me-N6-Me-ATP


3'-O-(2-nitrobenzyl)-2'-Deoxyadenosine-5'-Triphosphate

3'-O-(2-nitrobenzyl)-2'-Deoxyadenosine-5'-Triphosphate

3'-O-(2-nitrobenzyl)-2'-dATP


3'-O-(2-nitrobenzyl)-2'-Deoxyinosine-5'-Triphosphate

3'-O-(2-nitrobenzyl)-2'-Deoxyinosine-5'-Triphosphate

3'-O-(2-nitrobenzyl)-2'-dITP


3'-Deoxyadenosine-5'-Triphosphate

3'-Deoxyadenosine-5'-Triphosphate

3'-dATP


3'-Deoxyguanosine-5'-Triphosphate

3'-Deoxyguanosine-5'-Triphosphate

3'-dGTP


3'-Deoxycytidine-5'-Triphosphate

3'-Deoxycytidine-5'-Triphosphate

3'-dCTP


3'-Deoxy-5-Methyluridine-5'-Triphosphate

3'-Deoxy-5-Methyluridine-5'-Triphosphate

5-Methyl-3'-dUTP


3'-Deoxyuridine-5'-Triphosphate

3'-Deoxyuridine-5'-Triphosphate

3'-dUTP


2',3'-Dideoxyadenosine-5'-Triphosphate

2',3'-Dideoxyadenosine-5'-Triphosphate

ddATP


2',3'-Dideoxyguanosine-5'-Triphosphate

2',3'-Dideoxyguanosine-5'-Triphosphate

ddGTP


2',3'-Dideoxyuridine-5'-Triphosphate

2',3'-Dideoxyuridine-5'-Triphosphate

ddUTP


2',3'-Dideoxythymidine-5'-Triphosphate

2',3'-Dideoxythymidine-5'-Triphosphate

ddTTP


2',3'-Dideoxycytidine-5'-Triphosphate

2',3'-Dideoxycytidine-5'-Triphosphate

ddCTP, Zalcitabine triphosphate


3'-Azido-2',3'-dideoxyadenosine-5'-Triphosphate

3'-Azido-2',3'-dideoxyadenosine-5'-Triphosphate

3'-Azido-ddATP


3'-Azido-2',3'-dideoxyguanosine-5'-Triphosphate

3'-Azido-2',3'-dideoxyguanosine-5'-Triphosphate

3'-Azido-ddGTP


3'-Azido-2',3'-dideoxythymidine-5'-Triphosphate

3'-Azido-2',3'-dideoxythymidine-5'-Triphosphate

3'-Azido-ddTTP, AZTTP, AZT-TP, Zidovudine Triphosphate, Azidothymidine Triphosphate


3'-Amino-2',3'-dideoxyadenosine-5'-Triphosphate

3'-Amino-2',3'-dideoxyadenosine-5'-Triphosphate

3'-Amino-ddATP


3'-Amino-2',3'-dideoxycytidine-5'-Triphosphate

3'-Amino-2',3'-dideoxycytidine-5'-Triphosphate

3'-Amino-ddCTP


3'-Amino-2',3'-dideoxyguanosine-5'-Triphosphate

3'-Amino-2',3'-dideoxyguanosine-5'-Triphosphate

3'-Amino-ddGTP


3'-Amino-2',3'-dideoxythymidine-5'-Triphosphate

3'-Amino-2',3'-dideoxythymidine-5'-Triphosphate

3'-Amino-ddTTP


 

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