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You are at: All > Nucleotides > Nucleotides by Structural Class > Sugar Modified Nucleoside Triphosphates

N-1007
2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate
2'-F-dATP

2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate

Extinction Coefficient: 15,400 Lmol-1cm-1 at 258 nm
Molecular Weight: 509.2 g/mol (free acid)
Molecular Formula: C10H15N5O12P3F (free acid)
Salt Form: Lithium
Purity Specification: ≥95% by AX-HPLC
 
Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL

 
Certificate(s) of Analysis




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Reference(s)
Lauridsen LH, Rothnagel JA, Veedu RN. Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers. Chembiochem. 2012 Jan 2;13(1):19-25.
Cozens C, Pinheiro VB, Vaisman A, Woodgate R, Holliger P. A short adaptive path from DNA to RNA polymerases. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8067-72.
Reif R, Haque F, Guo P. Fluorogenic RNA Nanoparticles for Monitoring RNA Folding and Degradation in Real Time in Living Cells. Nucleic Acid Ther. 2012 Oct 31. doi:10.1089/nat.2012.0380.
Scarth BJ, White KL, Chen JM, Lansdon EB, Swaminathan S, Miller MD, Gotte M. Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase. Antimicrob Agents Chemother. 2011 Jun;55(6):2662-9.
Kanwar JR, Roy K, Kanwar RK. Chimeric aptamers in cancer cell-targeted drug delivery. Crit Rev Biochem Mol Biol. 2011 Dec;46(6):459-77.
Stockman BJ. 2-Fluoro-ATP as a versatile tool for 19F NMR-based activity screening. (2008) Journal of American Chemical Society, (130)(18): 5870-5871.
Cho HD, Oyelere AK, Strobel SA, Weiner AM. Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection. (2003) RNA, 3(8): 970-81.
Rhie A, et al. Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion. (2003) J. Biol. Chem., 278: 39697-705.
Sun LQ, Cairns MJ, Saravolac EG, Baker A, Gerlach WL. Catalytic nucleic acids: From lab to application. (2000) Pharmacological Reviews, 52: 325-347.
Genini D, Budihardjo I, Plunkett W, Wang X, Carrera CJ, Cottam HB, Carson DA, Leoni LM. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem. 2000 Jan 7;275(1):29-34.
Jayasena SD. Aptamers: An emerging class of molecules that rival antibodies in diagnostics. (1999) Clinical Chemistry, 45(9): 1628-1650.
Ono T, Scalf M, Smith LM. 2'-Fluoro modified nucleic acids: polymerase-directed synthesis, properties and stability to analysis by matrix-assisted laser desorption/ionization mass spectrometry. (1997) Nucleic Acids Res., 25(22): 4581-8.
Ono T, Scalf M, Smith LM. 2'-Fluoro modified nucleic acids: polymerase-directed synthesis, properties and stability to analysis by matrix-assisted laser desorption/ionization mass spectrometry. Nucleic Acids Res. 1997 Nov 15;25(22):4581-8.


 

 


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