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Nucleotides by Structural Class
Sugar Modified Nucleoside Triphosphates
at 271 nm
485.2 g/mol (free acid)
≥95% by AX-HPLC
Typically Shipped at 100 mM in H
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL
Certificate(s) of Analysis
2'-Fluoro NTPs are being utilized in an increasing number of applications in research and new drug development. 2'-Fluoro-dCTP is incorporated in both DNA and RNA constructs to improve
stability. Both 2' Fluoro dC and dU are used in the design and synthesis of
, antagomirs and siRNA, because they impart increased target affinity and resistance to endonuclease degradation, while reducing immune response.
A key technique utilized in aptamer development using 2'-Fluoro-dCTP is SELEX (Systematic Evolution of Ligands by Exponential Enrichment). The SELEX process allows for the simultaneous screening of 1 x 1015 different oligonucleotides against a target of interest, such as a protein. The main goal of SELEX is to identify a small subset of aptamers from the original library that bind to the target of interest. Learn more in the technical article:
An Overview of the SELEX Process
"TriLink offers not just better pricing but specialized services at large scale and functional, quality 2’-Fluoro-dCTP and 2’-Fluoro-dUTP. TriLink’s technical customer support was knowledgeable and gave me confidence about the products."
University of Washington, Seattle
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1 µmole ($53.00)
5 µmoles ($146.00)
10 µmoles ($265.00)
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10 x 10 µmoles ($1,390.00)
Related Products :
2'-Modified Thermostability Enhancer Set
Related Categories :
Sugar Modified Nucleoside Triphosphates
Drug Discovery, SELEX
Nucleotides by Catalog Number
Cytidine Triphosphate Analogs
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Nicol, C., Bunka, D.H.J., Blair, G.E., Stonehouse, N.J. Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein (2011) Biomedical and Biophysical Research Communications, 405: 417-421.
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Prakasha Gowda AS, Polizzi JM, Eckert KA, Spratt TE. Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. (2010) Biochemistry, (49)(23): 4833-4840.
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Tahiri-Alaoui A, et al. High affinity nucleic acid aptamers for streptavidin incorporated into bi-specific capture ligands. (2002) Nucleic Acids Res., 30(10): e45.
Capodici J, Kariko K, Weissman D. Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. (2002) J Immunol., 169(9): 5196-201.
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