Extinction Coefficient: 15,567 Lmol-1cm-1 at 265 nm
Molecular Weight: 521.2 g/mol (free acid)
Molecular Formula: C11H18N5O13P3 (free acid)
Salt Form: Lithium
Purity Specification: ≥90% by AX-HPLC
Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL
N6-methyl adenosine (N6-methyl ATP) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs (Meyer et al.). N6-methyl ATP can substitute for ATP in some biological systems, and is a potent agonist for P2Y-purinoceptors in the guinea pig, taenia coli (Burnstock et al.). In vitro studies showed that N6-methyl ATP substituted for ATP and supported cytoskeletal filament-driven translocation of motor proteins (dynein, kinesin and myosin) (Schliwa et al. & Shimizu et al.).
N6-methyl ATP is also a substrate for RNA polymerase and can be used for preparation of modified RNA (Rohayem & Kariko et al.).