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You are at: All > Nucleotides > Nucleotides by Structural Class > Sugar Modified Nucleoside Triphosphates

N-1016
2'-O-Methylcytidine-5'-Triphosphate
2'-O-Methyl-CTP, 2'OMe-CTP

2'-O-Methylcytidine-5'-Triphosphate

Extinction Coefficient: 9,100 Lmol-1cm-1 at 271 nm
Molecular Weight: 497.1 g/mol (free acid)
Molecular Formula: C10H18N3O14P(free acid)
Salt Form: Lithium
Purity Specification: ≥98% by AX-HPLC 

Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL


 
Certificate(s) of Analysis
 



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Reference(s)
Kong L, Li S, Liao Q, Zhang Y, Sun R, Zhu X, Zhang Q, Wang J, Wu X, Fang X, Zhu Y. Oleanolic acid and ursolic acid: Novel hepatitis C virus antivirals that inhibit NS5B activity. Antiviral Res. 2013 Feb 16;98(1):44-53.
Lauridsen LH, Rothnagel JA, Veedu RN. Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers. Chembiochem. 2012 Jan 2;13(1):19-25.
Kanwar JR, Roy K, Kanwar RK. Chimeric aptamers in cancer cell-targeted drug delivery. Crit Rev Biochem Mol Biol. 2011 Dec;46(6):459-77.
Xiao Z, et. al. Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection. ACS Nano. 2012 Jan 3. doi: 10.1021/nn204165v
Brown JA, Fiala KA, Fowler JD, Sherrer SM, Newmister SA, Duym WW, Suo Z. A novel mechanism of sugar selection utilized by a human X-family DNA polymerase. (2010) J Mol Biol. 15;395(2):282-90.
Brown JA, Fowler JD, Suo Z. Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase. (2010) Biochemistry, (49)(26): 5504-5510
Kariko K, Muramatsu H, Welsh F, et al. Incorporation of Pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. (2008) Molecular Therapy (16)11: 1833-1840.
Dutartre H, et. al. General catalytic deficiency of hepatitis C virus RNA polymerase with an S28T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues. Antimicrob Agents Chemother. 2006 Dec;50(12):4161-9.
Tomassini JE, et al. Inhibitory effect of 2'-substituted nucleosides on Hepatitis C virus replication correlates with metabolic properties in replicon cells. (2005) Antimicrobioal Agents and Chemotherapy, 49(5): 2050-2058.
Fa M, et al. Expanding the substrate repertoire of a DNA polymerase by directed evolution. (2004) JACS, 126(6): 1748-1754.
Carroll SS, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84. Epub 2003 Jan 27.
Padilla R, Sousa R. A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs. (2002) Nucleic Acids Res., 30(24): e138.


 

 


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