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You are at: All > Nucleotides > Nucleotides by Structural Class > Sugar Modified Nucleoside Triphosphates

N-1018
2'-O-Methyluridine-5'-Triphosphate
2'-O-Methyl-UTP, 2'OMe-UTP

2'-O-Methyluridine-5'-Triphosphate

Extinction Coefficient: 10,100 Lmol-1cm-1 at 262 nm
Molecular Weight: 498.2 g/mol (free acid)
Molecular Formula:  : C10H17N2O15P(free acid)
Salt Form: Lithium
Purity Specification: ≥90% by AX-HPLC 

Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL


 
Certificate(s) of Analysis
T1-CNZ01A-1



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Reference(s)
Lauridsen LH, Rothnagel JA, Veedu RN. Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers. Chembiochem. 2012 Jan 2;13(1):19-25.
Green NM, Moody KS, Debatis M, Marshak-Rothstein A. Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands. J Biol Chem. 2012 Sep 27. doi: 10.1074/jbc.M112.383000jbc.M112.383000.
Kanwar JR, Roy K, Kanwar RK. Chimeric aptamers in cancer cell-targeted drug delivery. Crit Rev Biochem Mol Biol. 2011 Dec;46(6):459-77.
Xiao Z, et. al. Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection. ACS Nano. 2012 Jan 3. doi: 10.1021/nn204165v
Kariko K, Muramatsu H, Welsh F, et al. Incorporation of Pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. (2008) Molecular Therapy (16)11: 1833-1840.
Padilla R, Sousa R. A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs. (2002) Nucleic Acids Res., 30(24): e138.


 

 


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