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You are at: All > Nucleotides > Nucleotides by Structural Class > Base Modified Ribonucleoside Triphosphates

N-1024
5-Methyluridine-5'-Triphosphate
5-Methyl-UTP, 5-Me-UTP, 5-mUTP

5-Methyluridine-5'-Triphosphate

Extinction Coefficient: 9,650 Lmol-1cm-1 at 267 nm
Molecular Weight: 498.2 g/mol (free acid)
Molecular Formula:  : C10H17N2O15P(free acid)
Salt Form: Lithium
Purity Specification: ≥90% by AX-HPLC

Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL


 
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Reference(s)
Nilsen TW. Detecting RNA-Protein Interactions by Photocross-Linking Using RNA Molecules Containing Uridine Analogs. Cold Spring Harb Protoc. 2013 Mar 1;2013(3). doi: 10.1101/pdb.prot073569.
Pardi N, Muramatsu H, Weissman D, Karikó K. In vitro transcription of long RNA containing modified nucleosides. Methods Mol Biol. 2013;969:29-42. doi: 10.1007/978-1-62703-260-5_2.
Motorin Y, Helm M. RNA nucleotide methylation. Wiley Interdiscip Rev RNA. 2011 Sep-Oct;2(5):611-31.
Schein CH, Oezguen N, van der Heden van Noort GJ, Filippov DV, Paul A, Kumar E, Braun W. NMR solution structure of poliovirus uridylyated peptide linked to the genome (VPgpU). (2010) Peptides. 31(8):1441-8.
Anderson, B., Muramatsu, H., Nallagatla, S.R., Bevilacqua, P.C., Sansing, L.H., Weissman, D. & Kariko, K. Incorporation of pseudouridine into mRNA enhances translation by dimishing PKR activation (2010) Nucleic Acids Research, 38(17): 5884-5892.
Kariko K, Muramatsu H, Welsh F, et al. Incorporation of Pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. (2008) Molecular Therapy (16)11: 1833-1840.
Belliot G, Sosnovtcev SV, Chang KO, Babu V, Uche U, Arnold JJ, Cameron CE, Green KY. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. (2005) Journal of Virology, 79(4): 2393-2403.
Kariko, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modifiation and the Evolutionary Origin of RNA (2005). Immunity, 23(2), 165-175.
Lefmann M, et al. Novel Mass Spectrometry-based tool for genotypic identification of mycobacteria. (2004) Journal of Clinical Microbiology, 42(1): 339-346.
Hartmer R, Storm N, Boecker S, Rodi CP, Hillenkamp F, Jurinke C, van den Boom D. RNase T1 mediated base-specific cleavage and MALDI-TOF MS for high-throughput comparative sequence analysis. (2003) Nucleic Acids Res., 31(9): e47.
Meyer PR, et. al. Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 2002 May;46(5):1540-5.
Nguyen A, Zhao C, Dorris D, Mazumder A. Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: differential effects on signal intensities and impacts on expression ratios. (2002) BMC Biotechnology, 2(1): 14.


 

 


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