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You are at: All > Nucleotides > Nucleotides by Structural Class > Sugar Modified Nucleoside Triphosphates

N-1028
2'-Azido-2'-deoxycytidine-5'-Triphosphate
2'-Azido-dCTP

2'-Azido-2'-deoxycytidine-5'-Triphosphate

Extinction Coefficient: 9,100 Lmol-1cm-1 at 271 nm
Molecular Weight: 508.2 g/mol (free acid)
Molecular Formula: C9H15N6O13P(free acid)
Salt Form: Lithium
Purity Specification: ≥90% by AX-HPLC 

Typically shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL


 
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Reference(s)
Lauridsen LH, Rothnagel JA, Veedu RN. Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers. Chembiochem. 2012 Jan 2;13(1):19-25.
Cozens C, Pinheiro VB, Vaisman A, Woodgate R, Holliger P. A short adaptive path from DNA to RNA polymerases. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8067-72.
Kumaki Y, Day CW, Smee DF, Morrey JD, Barnard DL. In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic N1N1 virus infections. (2011) Aniviral Reseach,
Padilla R, Sousa R. A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs. (2002) Nucleic Acids Res., 30(24): e138.
Kasrayan A, Persson AL, Sahlin M, Sjoberg BM. The conserved active site asparagine in class I ribonucleotide reductase is essential for catalysis. (2002) J Biol Chem., 277(8): 5749-55.
Sun LQ, Cairns MJ, Saravolac EG, Baker A, Gerlach WL. Catalytic nucleic acids: From lab to application. (2000) Pharmacological Reviews, 52: 325-347.
Maga G, et. al. Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase. Nucleic Acids Res. 1999 Feb 15;27(4):972-8.
Jayasena SD. Aptamers: An emerging class of molecules that rival antibodies in diagnostics. (1999) Clinical Chemistry, 45(9): 1628-1650.
Palmer S, Cox S. Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea. (1997) Antimicrobial Agents & Chemotherapy, 41(2): 460-4.


 

 


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