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You are at: All > Nucleotides > Nucleotides by Structural Class > Base Modified Ribonucleoside Triphosphates

N-1042
N1-Methyladenosine-5'-Triphosphate
N1-Methyl-ATP

N<sup>1</sup>-Methyladenosine-5'-Triphosphate

Extinction Coefficient: 14,600 Lmol-1cm-1 at 258 nm
Molecular Weight: 521.2 g/mol (free acid)
Molecular Formula: C11H18N5O13P3 (free acid)
Salt Form: Lithium
Purity Specification: ≥90% by AX-HPLC 

Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL


 
Certificate(s) of Analysis
T1-AKE01A-4
T1-AKE01A-1



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   1 µmole ($86.00)
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Reference(s)
Andries O,Mc Cafferty S,et al.N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.J Control Release. 2015 Sep 3
Motorin Y, Helm M. RNA nucleotide methylation. Wiley Interdiscip Rev RNA. 2011 Sep-Oct;2(5):611-31.
Kariko K, Muramatsu H, Welsh F, et al. Incorporation of Pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. (2008) Molecular Therapy (16)11: 1833-1840.


 

 


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