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You are at: All > Nucleotides > Nucleotides by Structural Class > Sugar Modified Nucleoside Triphosphates

N-4008
3'-Azido-2',3'-dideoxyguanosine-5'-Triphosphate
3'-Azido-ddGTP

3'-Azido-2',3'-dideoxyguanosine-5'-Triphosphate

Extinction Coefficient: 13,600 Lmol-1cm-1 at 252 nm
Molecular Weight: 532.2 g/mol (free acid)
Molecular Formula: C10H15N8O12P3 (free acid)
Salt Form: Lithium
Purity Specification: ≥90% by AX-HPLC

Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL


MSDS

Certificate(s) of Analysis
N-4008-061902



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Reference(s)
Herman BD, et. al. Substrate mimicry: HIV-1 reverse transcriptase recognizes 6 modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs. (2011) Nucleic Acids Research. Nucleic Acids Res. 2012 Jan;40(1):381-90.
Hanes J, Johnson K. A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase, Nucleic Acid Research.
Parikh UM, et. al. In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase. Antimicrob Agents Chemother. 2005 Mar;49(3):1139-44.
Sluis-Cremer N, et. al. The 3'-Azido group is not the primary determinant of the 3'-Azido-3'-deoxythymidine (AZT) responsible for the excision of AZT-resistant HIV-1. J Biol Chem. 2005 Aug 12;280(32):29047-52.
Strahl C, Blackburn EH. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. (1996) Mol Cell Biol., 16(1): 53-65.
Ueno T, Shirasaka T, Mitsuya H. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates. (1995) J Biol Chem., 270(40): 23605-11.


 

 


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