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You are at: All > Oligonucleotides > Custom Oligonucleotide Components > Custom Oligonucleotide Components by Type > Inverted Bases

3'-3' Modifications

 



3'-3' Modifications

Oligonucleotide Modification Price
3' Terminus
5.0 µmole $252
10 µmole $336
15 µmole $420
Internal
5.0 µmole $189
10 µmole $252
15 µmole $315

There are many applications for reverse linked nucleotide modifications of oligonucleotides. They impart nuclease resistance and allow the study of strand orientation effects on molecular biological function. When placed internally the remaining portion of the oligo must be synthesized with reversed polarity. This and other such complicated constructs, must be quoted on a case-by-case basis. See internal modification prices to determine the cost of the reversed polarity portion of your oligonucleotide, if applicable.



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Reference(s)
Chan CW, Kaplan W, Parish CR, Khachigian LM. Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme. PLoS One. 2012;7(7):e39160.
Cai H, et. al. DNAzyme Targeting c-jun Suppresses Skin Cancer Growth. Sci Transl Med. 2012 Jun 20;4(139):139ra82.
Bhindi R, Fahmy RG, McMahon AC, Khachigian LM, Lowe HC. Intracoronary Delivery of DNAzymes Targeting Human EFR-1 Reduces Infarct Size Following Ischaemia Reperfusion. (2011) The Journal of Pathology. DOI: 10.1002/path.2991


 

 


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