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You are at: All > Nucleotides > Nucleotides by Structural Class > Base Modified Deoxynucleoside Triphosphates

N-2060
5-Hydroxymethyl-2’-deoxycytidine-5’-Triphosphate
5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP

5-Hydroxymethyl-2’-deoxycytidine-5’-Triphosphate

Extinction Coefficient: 7,700 Lmol-1cm-1 at 275 nm
Molecular Weight: 497.1 g/mol (free acid)
Molecular Formula: C10H18N3O14P3(free acid)
Salt Form: Li+
Purity Specification: ≥90% by AX-HPLC

Shipped at 100 mM in H2O.
1 µmole: 10 µL
5 µmole: 50 µL
10 µmole: 100 µL

MSDS

Certificate(s) of Analysis
T1-BNA01A-2

T1-BNA01A-3

T1-BNA02A

T1-BNA01A

N2060-T1WE01A




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Reference(s)
Li Z, Gu TP, Weber AR, Shen JZ, Li BZ, Xie ZG, Yin R, Guo F, Liu X, Tang F, Wang H, Schär P, Xu GL.Gadd45a promotes DNA demethylation through TDG.Nucleic Acids Res. 2015 Apr 6
Li Z, Gu TP, Weber AR, Shen JZ, Li BZ, Xie ZG, Yin R, Guo F, Liu X, Tang F, Wang H, Schär P, Xu GL.Gadd45a promotes DNA demethylation through TDG.Nucleic Acids Res. 2015 Apr 30
Requena CE, Pérez-Moreno G, Ruiz-Pérez LM, Vidal AE, González-Pacanowska D. The NTP pyrophosphatase DCTPP1 contributes to the homeostasis and cleansing of the dNTP pool in human cells. Biochem J. 2014 Jan 27. doi:10.1042/BJ20130894
McKernan KJ, Spangler J, Zhang L, Tadigotla V, McLaughlin S, Warner J, Zare A, Boles RG. Expanded genetic codes in next generation sequencing enable decontamination and mitochondrial enrichment. PLoS One. 2014 May 2;9(5):e96492.
Mellén M, Ayata P, Dewell S, Kriaucionis S, Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell. 2012 Dec 21;151(7):1417-30.
Munzel M, Globisch D, Carell T. 5-Hydroxymethylcytosine, the sixth base of the genome. Angew Chem Int Ed Engl. 2011 Jul 11;50(29):6460-8.
Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol. 2010 Sep;11(9):607-20.


 

 


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