My Account | Shopping Cart | Contact
Trilink Biotech Logo

Oligonucleotides | mRNA & Long RNA | Nucleotides | CleanCap™ | CleanTag™ | CleanAmp™ | Custom Chemistry | GMP

OligoBuilder® | Nucleotides List | Stocked mRNA List | DNA Synthesis Reagents List | CleanAmp™ Products List


You are at: All > Bioconjugation Reagents > Accessories

S-2005
2-Sulfobenzaldehyde


2-Sulfobenzaldehyde

2-Sulfobenzaldehyde is a water-soluble aromatic aldehyde reagent used to quantify the molar substitution ratio (MSR) of HyNic-modified proteins or other biomolecules. This aromatic aldehyde reacts with HyNic-modified biomolecules and forms a quantifiable hydrazone absorbance signature at 345 nm (molar extinction coefficient @ 345 nm = 28,500). This signature is used to determine the number of HyNic groups incorporated in a protein or other biomolecule after modification with S-HyNic. S-HyNic-modified proteins or biomolecules can be conjugated to S-4FB-modified biomolecules using Chromalink™ technology.

Chromalink™ technology is an innovative, catalyzed, UV-traceable, heterobifunctional linker technology that offers greater efficiency and yield in a considerably simpler method for linking any two biomolecules together e.g. proteins, oligos, or peptides regardless of molecular weight.

  • S-HyNic (succinimidyl-6-hydrazino-nicotinamide) linker is conjugated to biomolecule 1 through primary amines (-NH2) on the amino acid, lysine, or on the N-terminus.
  • S-4FB (succinimidyl-4-formylbenzamide) linker is conjugated to biomolecule 2 through primary amines (-NH2) on the amino acid, lysine, or on the N-terminus.
  • HyNic-modified biomolecule 1 is incubated with 4FB-modified biomolecule 2 in a catalyzed conjugation reaction.

The result is two biomolecules conjugated through a UV-traceable, stable bond (bis-arylhydrazone) with measurable absorbance at 354 nm. 

Additional Information

Certificate(s) of Analysis

Not for resale without express written permission. Not for use in humans. No license under any patent or patent pending is granted or implied by the purchase of any TriLink product. TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser’s sole responsibility.

 




Email a Friend
Product Inquiry
    
Ready To Order?

Please select a size :
   100 mg ($183.00)


 



Related Products :

Related Categories :




 

 


  Twitter Twitter Facebook Facebook Linked In Linked In RSS RSS Google RSS  
© 2017 TriLink BioTechnologies, LLC | All Rights Reserved