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You are at: All > Oligonucleotides > Custom Oligonucleotide Components > Custom Oligonucleotide Components by Type > Modified Bases > Wobble and Universal Bases

Wobble Site
Random Site, Degenerate Site

Wobble Site

TriLink offers the standard IUPAC wobble options, as well as custom wobbles (randomers). We hand mix our amidites and supports to ensure a proper distribution at each site in your oligonucleotide, may that be 1:1:1:1 or a custom ratio.

TriLink has done extensive research to optimize the "n" wobble (A, C, G, T) to achieve as close to a 1:1:1:1 equal ratio as possible in the final oligo product. To order your oligo with wobble site(s), build your oligo in OligoBuilder® using the 'Wobble Sites' menu. If a custom (unequal) base ratio is required, please indicate this in the Notes section.

Common Wobble Sites
IUPAC Code DNA Base Mixture RNA Base Mixture
n A, C, G, T A, C, G, U
B C ,G, T C ,G, U
D A, G, T A, G, U
H A, C, T A, C, U
V A, C, G A, C, G
M A, C A, C
R A, G A, G
W A, T A, U
S C, G C, G
Y C, T C, U
K G, T G, U

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