Back to top

A Revolution in mRNA Capping

Enabling the Development of Groundbreaking Treatments
and Lifesaving Vaccines

A Revolution in mRNA Capping

Enabling the Development of Groundbreaking Treatments
and Lifesaving Vaccines

mRNA technology has made rapid advancements in the past decade. This progress would not have been possible without innovative tools like CleanCap® reagents, which introduced new levels of performance and efficiency to mRNA manufacturing.

Legacy mRNA Capping Methods Still in Use

mCAP Co-transcriptional
First-generation cap analog, yielding only 50% capping efficiency and a Cap 0 structure

Anti-Reverse Cap Analog (ARCA)
Co-transcriptional capping method that creates a Cap 0 structure with ~70% capping efficiency

Enzymatic Capping Post-transcriptional
Capping method that requires multiple reaction and purification steps

The Future of Capping is Here to Help
Get You to Market Faster

CleanCap_Logo

By modifying the structure of a traditional cap analog, we created CleanCap technology. The evolved cap analog produces a Cap 1 structure incorporated by RNA polymerase in a single in vitro transcription reaction to increase efficiency while reducing process time.

  • Higher quality mRNA with 95% capping efficiency
  • Higher transcriptional yield per mL
  • Reduced immunogenicity due to the natural Cap 1 structure
  • One-pot solution with fewer manufacturing steps

Patented in 2015 and cited in thousands of publications

Available in both research and GMP grade

Used in the production of >3 billion doses of COVID-19 vaccine

Tried and Trusted Technology

Used in global commercial manufacturing programs, including a leading COVID-19 vaccine, CleanCap technology has proven to be the optimal mRNA vaccine capping method. See how we ramped up production to meet unprecedented demands in the global pandemic. View case study >

Ready to Elevate Your mRNA Capping Process?

Talk to our team about what may be the best option for you. Fill out the form below to get started.

CleanCap mRNA Capping

CleanCap mRNA Capping

""