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CleanCap® Reagent AU - (N-7114)

CleanCap® AU for Self-Amplifying mRNA, CleanCap® Reagent AU for co-transcriptional capping of mRNA, m7G(5')ppp(5')(2'OMeA)pU
In stock
Product SKU Unit Size Price Qty
N-7114-1 1 µmole
N-7114-5 5 µmole
N-7114-10 10 µmole
N-7114-100 100 µmole



TriLink's patented CleanCap® Reagent AU is designed for the co-transcriptional capping of mRNA to produce an mRNA with naturally occurring Cap 1. CleanCap Reagent AU was specifically designed for self-replicating RNAs based on the genomes of positive sense strand RNA viruses such as Venezuelan equine encephalitis virus (VEEV), Semliki forest virus (SFV), and Sindbis virus (SIN).

The positive sense strand genomes of these viruses start with a 5’ AU structure. Cap 1 mRNAs have superior in vivo activity compared to Cap 0 mRNA produced by legacy co-transcriptional capping methods like anti-reverse cap analog (ARCA).

PLEASE NOTE: CleanCap Reagent AU requires an AU initiator. To learn more, please review the Product Insert below.

TriLink's patented CleanCap reagents are available in “Research Use” grade as well as GMP-grade “For Further Processing.” GMP product is manufactured in accordance with ISO 9001:2015 and Quality Standards as defined in a GMP Quality Agreement.

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Product details
Catalog No N-7114
Purity ≥95% by AX-HPLC
Extinction Coefficient 33,400 Lmol-1cm-1 at 258 nm
Molecular Formula C31H42N12O25P4 (free acid)
Molecular Weight 1106.6 g/mole (free acid)
Salt Form Na+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) CleanCap® AU for Self-Amplifying mRNA, CleanCap® Reagent AU for co-transcriptional capping of mRNA, m7G(5')ppp(5')(2'OMeA)pU
Application CRISPR, In vitro Transcription, Recombinases, TALENS, Transposases, Vaccine Development, Zinc Finger Nucleases
Backbone 5'-5'-Triphosphate
Base Analog(s) Adenosine, Uridine
Sugar Type(s) RNA
Nucleotide Category Cap analogs
Cap Analogs CleanCap Cap Analogs
Technical documents

CleanCap AU Reagent (N-7114) Product Insert

N-7114 Safety Data Sheet

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Certificate of analysis

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Intellectual property

CleanCap capping technology For Research Use Only. Not for use in humans. Not for use in diagnostic or therapeutic purposes. For additional licensing restrictions, please see the license agreement at Patents and patent pending, see

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.

TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.