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Sept eNews

Research Update

TALEN mRNA Efficiently Generates Transgenic Mice

The gene therapy field has been revolutionized by the introduction of transcription activator-like effector nucleases (TALENs). Though genetic manipulation had long been a tool to delineate gene function, methods were cumbersome and time consuming, until Zinc finger nucleases (ZFNs) were discovered. ZFNs provided, for the first time, an efficient and relatively simple method for inducing site-specific modifications of genes. However, ZFN design has proven to be difficult and they have been associated with nonspecific cleavage and cytotoxicity. TALENs quickly and efficiently edit genomic DNA in a variety of cell types with greater specificity.

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Upcoming Events
Visit our poster presentations at Tri-Con, AGBT, AAFS & NGS.

New Poster
Improved Small RNA Library Preparation Workflows for NGS

 
Blog Post

Sex, Money and Brains:
What do They Have in Common?

  • Human brain connectome: the last frontier?
  • Is the UK making a real HAL 9000?
  • MRI imaging of love and other emotions.

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Brain Valentine

Nerdy Valentine by PinkOrchidPress

 
Custom TALEN mRNA Synthesis

The TriLink Team is experienced in TALEN mRNA synthesis. We can modify your construct to reduce innate immune stimulation and offer mRNA expression vectors designed to easily accept a TALEN cloned using the Golden Gate method.

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New Products

Cas9 Nickase mRNA
Mutagenesis dNTP Mix
5-Formyl-dUTP
N6-Methyl-Amino-ATP
Desthiobiotin-6-dCTP
Factor IX mRNA
RNA Library for RNA Aptamer Selection
 

 

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