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March eNews

Research Update

Simple and Robust Detection of N6-methyladenosine Modified RNA

Methylation has been a topic of intense investigation in the field of epigenetics. The most commonly studied methylation sites occur on the cytosines of DNA which are dynamically modified in order to regulate gene expression. However, recent studies show that post-translational modifications to RNA may also influence protein expression. A prominent, yet poorly-studied base modification in non-coding RNA and mRNA is N6-methyladenosine (m6A).

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New Poster
Improved Small RNA Library
Prep Workflows for NGS

Giving Back
We donated 100’s of Red Bags. Thanks for your support!

Featured New Product
5-Carboxy-dUTP, the latest in our expanding epigenetics research reagent collection.

 
Blog Post

In Search of RNA Epigenetics: A Grand Challenge

  • Methylated riboA and riboC are the most commonly detected nucleobases in epigenetics research
  • Powerful new analytical methods are key tools
    for progress
  • Promising PacBio sequencing and novel “Pan Probes” reported

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N6-Methyl-A

 

 
Epigenetics Research Reagent Collection

NTPs:


N6-Methyl-ATP
5-Methyl-CTP
O6-Methyl-GTP
8-Oxo-GTP
5-Carboxy-CTP
5-Formyl-CTP
5-Hydroxymethyl-CTP
5-Carboxy-UTP
N6-Methyl-dATP
5-Methyl-dCTP
O6-Methyl-dGTP
8-Oxo-dGTP
N4-Methyl-dCTP
5-Hydroxymethyl-dUTP
5-Hydroxymethyl-dCTP
5-Carboxy-dCTP
5-Formyl-dCTP

Oligo Modifications:


N6-Methyl-dA
O6-Methyl-dG
8-Oxo-dA
8-Oxo-dG
5-Hydroxymethyl-dU
5-Methyl-dC
5-Methyl-C
5-Hydroxymethyl-dC
5-Carboxy-dC
5-Formyl-dC

Don’t see what you need?
Contact us to discuss a custom synthesis.
 

Previous Blog Post

Epigenetics 2.0 - Beyond DNA Methylation

Cytosine's Chemical Biology Gets "Curiouser and Curiouser!"

After following the White Rabbit down a large rabbit-hole, Lewis Carroll's Alice found that curious happenings in Wonderland became "curiouser and curiouser!" Reading about cytosine's curious chemical biology in epigenetics gave me the same impression, and left me a little dizzy wondering about what will be discovered next, and what it all means. Read More

 

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