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Research Update

Unexpected In Vivo Toxicity Supports Use of mRNA in CAR T-Cell Therapy

Researchers at Oslo University have discovered an important finding that may change the way scientists design certain types of T-cell therapies. T cells play a key role in cell-mediated immunity and in recent years scientists have learned how to isolate a patient’s own T cells, engineer the receptors to attack specific cells, such as cancer cells, and reintroduce them back into the patient.

The team, led by Jon Kyte, has been working on a T-cell therapy platform that utilizes transient expression of chimeric antigen receptors (CARs) to target leukemia and other blood-related cancers.

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mRNA Vaccine and Immunotherapy Development from Concept to Clinic

% Antigen Specific CD8 T Cells
 
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Vaccination with OVA mRNA(L-6328; L-6128) resulted in a high number of antigen specific CD8 T cells. See more data and full experimental details here.
 
Ask an Expert

What are the benefits of using mRNA over plasmid or viral-based approaches for vaccine and immunotherapy development?

mRNA offers several advantages over traditional plasmid and viral-based approaches: First, mRNA boasts a superior safety profile. As a transient carrier of genetic information, it is metabolized naturally and poses little to no risk of genomic integration.

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Zone in with Zon Blog Post

RNA in DNA?Mistake or Mystery?

  • Human DNA Misincorporates >1 mil Ribonucleotides Per Replication Cycle
  • These Mistakes are Likely Biological Mysteries
  • Four New Sequencing Methods May Demystify Why There?s ?R in DNA?
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