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Research Update

Using Modified Guide Strands and Cas9 mRNA to Enhance CRISPR-Cas9-mediated Gene Editing Efficiency in Primary Human Cells

Researchers at Stanford University using TriLink's Cas9 mRNA report that chemical modification of CRISPR RNA guide strands can enhance CRISPR-Cas9-mediated genome editing efficiency in human primary cells. They also identify mRNA as an optimal delivery vehicle for Cas9 when compared to plasmid.

The CRISPR-Cas9 system has revolutionized the field of genome editing due to its efficiency, ease of use, and cost effectiveness, however, gene editing in primary human cells has remained problematic. These findings are a major breakthrough for the CRISPR-Cas9 field, particularly therapeutic applications.

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