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Research Update

CleanAmp™ dNTPs Aid in Detection of Intra-amniotic Infections

Japanese researchers have developed a novel PCR assay for the detection of Ureaplasma, Mycoplasma and other bacteria and fungi in amniotic fluid samples (PLOS). Infection by these microorganisms can lead to the onset of preterm labor and perinatal morbidity. Additionally, infection of the infant in utero increases the risk of sepsis, pneumonia, bacteremia, and meningitis. Though total incidence of intra-amniotic infection (IAI) is unknown, it is estimated to occur in up to 40% of preterm labor cases <27 gestational weeks. Rapid detection and treatment is paramount for reducing the effects of IAI but conventional methods are lacking.

Currently, the “gold standard” for detection of IAI involves microbial cultures. This method is not ideal because it can take days to culture and many strains are difficult to cultivate.

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Profiling Pseudouridine

Why "Mother Nature" evolved an enzymatic process for molecular manipulation of U to Ψ at only a few positions in various RNAs?

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