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Research Update

Promising Treatment for Duchenne Muscular Dystrophy with Antisense Oligo Therapeutic Formulated with Carbohydrates

In the March 11 issue of Nature Communications researchers reported that formulating antisense oligonucleotides in a glucose/fructose-based infusion increased delivery and uptake to muscle resulting in improved treatment of Duchenne muscular dystrophy (DMD).

DMD is a genetic disease caused by the lack of functional dystrophin (Figure 1), which leads to  progressive muscle weakness. Currently, there are two antisense therapies for DMD in clinical trials; however, efficient systemic delivery has been a challenge, prompting the need for improved delivery methods...



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We're Celebrating Our 20th Anniversary and It All Began with Oligos

Since this newsletter is dedicated to oligos, it seems fitting to take a moment to reflect on our anniversary being that TriLink was founded to synthesize high-quality oligonucleotides. Established in May of 1996, we quickly became a leading oligo manufacturer, specializing in modified oligos with challenging constructs. TriLInk?s been going strong ever since, and we continue to operate at the forefront of nucleic acid innovation and development. The past 20 years have been an unbelievable journey and we look forward to the next 20 years.

We invite you to learn more about our history and explore all of our oligonucleotide products.


 
Ask an Expert

What are the advantages of using 2'OMe RNA bases in an oligonucleotide?

2' O-Methyl RNA is a more stable form of RNA with similar properties. It has the same low rate of depurination, but it is protected against base hydrolysis.

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Zone In With Zon Blog Post

Curiously Circular RNA
circRNA was serendipitously discovered in 1991 and has been shown by NGS sequencing to be ubiquitous. circRNA may also regulate gene expression much like antisense modified oligos are used to target miRNA.

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