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Research Update

Modified oligos from TriLink used to synthesize polymer-tagged nucleotides for new nanopore sequencing method

In an eNews article a while back, the 5’hexynyl group was highlighted as one possible oligo modification offered by TriLink to enable click chemistry, a very versatile conjugation method.  There are many applications for click chemistry, and recently TriLink 5’ hexynyl-modified oligonucleotides were used for a new nanopore sequencing method in which click chemistry is utilized to synthesize polymer-tagged nucleotides.

Nanopore sequencing is normally carried out by threading a strand of DNA through a protein-based nanopore and converting resultant ionic current fluctuations into nucleotide base sequence. A radically different strategy using 5’ hexynyl-modified oligonucleotides was recently reported in...


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