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Research Update

COPD Analysis Using CRISPR Technology

Researchers from Johns Hopkins University have discovered two novel frameshift mutations that predispose patients to pulmonary fibrosis (PF)-emphysema. They found that these single nucleotide polymorphisms (SNPs) are associated with decreased levels of NAF1 and shortened telomeres, the latter of which had previously been linked to patients with familial PF-emphysema.

Using TriLink’s Cas9 mRNA and custom long synthetic RNA, the authors showed that the disease-associated NAF1 mutations are functionally deleterious by disturbing entry of NAF1 into the nucleus and ultimately reducing telomerase stability.

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NGS Dimer Got You Down?

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Do you offer a kit for small RNA library prep that is compatible with the Ion Torrent™ sequencing platform?

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Zone In With Zon Blog Post

Chinese Scientists to Pioneer First Human CRISPR Clinical Trial

Now, even more exciting developments for CRISPR are on the horizon. Chinese researchers are poised for the first human clinical trial using CRISPR, and an analogous study in the US is awaiting FDA approval. Both of these trials involve forms of....

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