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Research Update

Targeted mRNA Delivery through Novel Polymeric Nanoparticles Confirmed using TriLink EGFP

Though delivery of nucleic acids has been studied for decades, emerging interest in therapeutic messenger RNAs (mRNAs) has led to renewed interest in biomaterials and nanotechnology platforms designed specifically for mRNA delivery. Despite many unique advantages of mRNA, its delivery has been challenging due to its large size, negative charge, and susceptibility to enzymatic degradation.

Of the biomaterials tested, lipid nanoparticles are perhaps the most well-characterized and variations of lipid nanoparticles constitute a large portion of commercially available options. However, although these cationic nanoparticles have been very effective in vitro, in vivo studies have shown that they can be quickly eliminated by the mononuclear phagocyte system.

Alternatively, polymeric nanoparticles contain several qualities that are advantageous for delivery of mRNA, including favorable electrostatic interactions with negatively charged nucleic acids. Though the optimization can be somewhat challenging, the polymeric nanoparticles can form...

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TIDES Oligonucleotide and Peptide Therapeutics Booth #305
4/30-5/3 San Diego, CA.

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5/10-5/13 Washington, DC.
Diagnostic and Therapeutic GMP Manufacturing

We offer a wide range of manufacturing scales enabling you to specify the exact amount of material for pre-clinical IND toxicology studies or early phase clinical trials. In addition to drug substances, we'll provide all the required supporting documentation to streamline the IND submission process and carry you through to clinical trials, making the process efficient and cost effective. TriLink delivers consistent quality API on schedule and on budget.

Manufacturing of therapeutic grade material is available for:

  • mRNA
  • Long RNA
  • Oligonucleotides
  • Nucleotides & nucleosides
  • Aptamers
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Ask An Expert

Do you offer small-scale oligonucleotides under GMP conditions?

Yes. We offer full GMP quality material at each scale we offer. However, we do not have a small scale synthesizer in the clean rooms, which are reserved for programs requiring each oligonucleotide to be synthesized one at a time in an exacting environment. Most of our small-scale oligonucleotide programs include multiple oligos being prepared simultaneously...

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Zone In With Zon Blog Post

DNA Day 2017

Deciding what to post here in recognition of DNA Day 2017 was just as challenging as it has been in past years, primarily because there’s so many different perspectives from which to choose. After much mulling, and several abandoned approaches, I settled on featuring DNA publications that have received the most citations, as an objective metric...

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