Twitter Facebook Linked In Zone In Google Plus 
Research Update

Hit-and-Run Programming with TriLink mRNA

Immune cell therapy has become a hot field, partially due to recent advancements in gene editing technologies and therapeutic delivery systems. These advancements improve immune cell therapy through a number of factors, including improved patient safety through greater control of gene expression and/or increased feasibility through ease of manufacturing.

Published last month in Nature Communications, researchers from University of Washington and Fred Hutchinson Cancer Research Center reported on a technology that improved both the safety and the feasibility of gene editing.

In this article, they describe a simple approach to the targeted delivery and transient expression of gene editing mRNA, a method they describe as hit-and-run programming. Specifically, they envelope TriLink custom mRNA in polymeric nanoparticles coupled with a cell-targeting molecule and then incubate the mRNA-containing nanoparticles with the target cell.

"This platform does not add complexity to manufacturing because it involves no special equipment or training. Thus, it can substantially streamline the manufacture of cell-based therapies at clinical scales, which means that treating patients with genetically engineered cells could become less expensive, and more effective as a disease-fighting intervention," the authors note...

Read More
CleanCap™ mRNA
TriLink's proprietary mRNA is the highest performing co-transcriptional capped mRNA available. Stocked CleanCap mRNA features a natural Cap1 structure and is available in most popular constructs or contact us for your custom mRNA construct.
Bioconjugation Services
Using our Chromalink® technology, our team of bioconjugation experts can perform custom conjugations to any biomolecule, including antibodies, oligos, proteins, peptides, aptamers, magnetic beads and even solid surfaces.
Come and See Us
Aptamers in Bordeaux
9/22-9/23 Bordeaux, FR
Oligo Therapeutics
Society (OTS)

9/24-9/27 Bordeaux, FR
TriLink mRNA: Setting the Standard for Quality and Performance

TriLink's portfolio of catalog and custom synthesis mRNA set the standard for quality and performance, with our proprietary CleanCap Technology to enhance and achieve superior translation. Products include gene editing, reporter gene, and expression factor constructs and are available in standard configurations or as a custom synthesis enabling a wide array of modification options and scales. All TriLink's mRNA products offer:

  • Custom tailored support to meet specific application or program needs

  • Wide variety of modification, treatment and purification options

  • Manufactured following a ISO9001:2008 quality system - GMP also avaliable

  • Need More Info Contact Us
    CleanCap™ EGFP 5moU
    14 Day Expression Analysis with Fuse-IT-mRNA CleanCap EGFP mRNA iPS derived cardiomyocytes Cor.-4U, axiogenesis, 6 minute fusion, 0.5ug of mRNA. Images courtesy of Beniag
    Ask An Expert

    What are the benefits of using mRNA over plasmid or viral-based approaches for vaccine and immunotherapy development?

    mRNA offers several advantages over traditional plasmid and viral-based approaches: mRNA boasts a superior safety profile. As a transient carrier of genetic information, itis metabolized naturally and poses little to no risk ...

    Read More
    Zone In With Zon Blog Post

    Highly Visible Invisible Food Safety

    • FDA Food Safety Act Focuses on Prevention Rather Than Response

    • PCR Powerful Approach for Assuring Foodborne Safety

    • Safer Food via Immuno-PCR Commercialized by Invisible Sentinel

    View Blog Post

    © 2017 TriLink BioTechnologies | All Rights Reserved