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Research Update

Hit-and-Run Programming with TriLink mRNA

Immune cell therapy has become a hot field, partially due to recent advancements in gene editing technologies and therapeutic delivery systems. These advancements improve immune cell therapy through a number of factors, including improved patient safety through greater control of gene expression and/or increased feasibility through ease of manufacturing.

Published last month in Nature Communications, researchers from University of Washington and Fred Hutchinson Cancer Research Center reported on a technology that improved both the safety and the feasibility of gene editing.

In this article, they describe a simple approach to the targeted delivery and transient expression of gene editing mRNA, a method they describe as hit-and-run programming. Specifically, they envelope TriLink custom mRNA in polymeric nanoparticles coupled with a cell-targeting molecule and then incubate the mRNA-containing nanoparticles with the target cell.

"This platform does not add complexity to manufacturing because it involves no special equipment or training. Thus, it can substantially streamline the manufacture of cell-based therapies at clinical scales, which means that treating patients with genetically engineered cells could become less expensive, and more effective as a disease-fighting intervention," the authors note...


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TriLink mRNA: Setting the Standard for Quality and Performance

TriLink's portfolio of catalog and custom synthesis mRNA set the standard for quality and performance, with our proprietary CleanCap Technology to enhance and achieve superior translation. Products include gene editing, reporter gene, and expression factor constructs and are available in standard configurations or as a custom synthesis enabling a wide array of modification options and scales. All TriLink's mRNA products offer:

  • Custom tailored support to meet specific application or program needs

  • Wide variety of modification, treatment and purification options

  • Manufactured following a ISO9001:2008 quality system - GMP also avaliable


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