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Research Update

Understanding the Genetic Basis of Skin Pigmentation with CRISPR/Cas9

Recently, an international group of scientists published a report in Science that identified a number of loci associated with skin pigmentation. They found a number of alleles that are strongly associated with both light and dark skin pigmentation, leading to insight as to how these traits may have differentiated over hundreds of thousands of years.

"While over 350 pigmentation genes have been identified in animal models, only a subset of these genes have been linked to normal variation in humans. Of these, there is limited knowledge about loci that affect pigmentation in populations with African ancestry," the authors note.

Skin pigmentation is known to be correlated to the geographic and environmental landscape and it has been proposed that darker skin pigmentation is a trait that has been selected in populations closer to the equator because it helps mitigate high levels of ultraviolet radiation. Alternatively, for populations living further from the equator, genes were driven towards lighter pigmentation to help processes dependent on sunlight, like Vitamin D synthesis...

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Ask An Expert

I’ve identified the target sequence for a CRISPR Cas9 gene editing experiment. What components do I need?

To attain unmatched consistency between your CRISPR experimental replicates use TriLink’s CleanCap Cas9 mRNA and high quality sgRNA. sgRNA, also known as Single Guide RNA a chimeric RNA composed of crRNA and tracrRNA, connected by a....

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Zone In With Zon Blog Post

RNA Epigenetics – Part 3

• 2'-O-Methylation Sites in Human mRNA Sequenced with Base Precision

• N3-Methylcytidine Discovered in Human mRNA

• "The More You Know, the More You Know You Don’t Know "-Aristotle

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