Twitter Facebook Linked In Zone In Google Plus 
Research Update

Cancer Marker PD-L1 Leads to a Potential Tool for Studying Metabolic Disorders

Recently as reported in Nature Nanotechnology, researchers used TriLink’s ChromaLink® Technology to help determine Programmed death-ligand 1 (PD-L1) expression in healthy mice.

PD-L1 is an important immune regulatory molecule linked to multiple types of cancer and has gained attention from drug companies in recent years.

Currently, there are several commercial immunotherapies targeting the PD-L1 pathway and recent clinical trial results have fueled a massive increase in immunotherapy-related cancer research.

"Despite the impressive gains in immunotherapy for cancer, heterogeneous outcomes necessitate new methods to monitor and predict patient responses. A method that comprehensively monitors PD-L1 expression could be of diagnostic value, and may help resolve lingering questions about the role of PD-L1 expression in checkpoint blockade responses," the authors explain.

With the help of ChromaLink NHS-biotin reagent, the authors developed a phage display to detect and isolate...

Read More
 
CleanCap™ mRNA
TriLink's proprietary mRNA is the highest purity co-transcriptional capped mRNA available. Stocked CleanCap mRNA features a natural Cap1 structure and is available in most popular constructs or contact us for your custom mRNA construct.
OligoBuilder®
Get instant pricing & ordering for modified and standard oligos from 0.2 µmole to 15 µmole synthesis scales.
Featured Product
5-Methoxy-UTP Cat# N-1093. Find what you need in our catalog of over 200 modified Nucleotides.
ChromaLink® Technology

ChromaLink is a patented, easy-to-use, single step, catalyzed linker technology that enables fast and quantitative conjugation of biomolecules under mild conditions resulting in higher efficiencies and yields.

ChromaLink Advantages:

  • Quantifiable – Using a UV signature wavelength and simple UV scan

  • Stable - 10 times more stable than any other conjugation linker

  • Specificity - Two component linker method avoids homoconjugate formation

  • Efficient - >80% efficient linker-biomolecule conjugations

ChromaLink Technology is available for purchase as a reagent, easy-to-use kits, derivatized magnetic beads, and in bulk packaging for research and commercial organizations.

 
CRISPR
 
Ask An Expert

Why use ChromaLink Biotin or ChromaLink Digoxigenin (DIG) labeling kits?

For maximum sensitivity and reproducibility, it is important to avoid over-labeling, which leads to reduced immunoreactivity, or under-labeling, which leads to a weak signal. ChromaLink Biotin and DIG Labeling Kits are the only kits which enable ....

Read More
Zone In With Zon Blog Post

Long Noncoding RNA (lncRNA) Revisited

• Publications Dealing with lncRNAs Show Exponential Growth

• Evidence for Involvement of lncRNAs in Cancer is Increasing

• Value of lncRNAs as Biomarkers Has Been Validated

View Blog Post


 

 
 
© 2018 TriLink BioTechnologies | All Rights Reserved