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Our facilites

Located in the San Diego biotech hub of Sorrento Valley, TriLink's campus consists of four state-of-the-art, custom-built manufacturing facilities. Our facilities were designed with flexibility and expansion in mind. Manufacturing space is divided across purpose-built suites, and individual floorplans can be modified to suit program needs. Our current configuration supports process development, oligonucleotide synthesis, custom mRNA synthesis, cGMP mRNA manufacturing, and more. The large footprint and customizable nature of our facilities enable continued expansion of our capabilities and production scale.

Campus of state-of-the-art facilities to support your nucleic acid program needs

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mRNA, raw material, and oligo manufacturing

  • 118,000 ft2 (10,963 m2)
  • Discovery and GMP mRNA manufacturing services
  • CleanCap® technology and NTP innovation and scale up
  • Oligo and custom chemistry manufacturing
  • On-site quality control lab
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Analytical and support services

  • Analytical Sciences Center of Excellence (ASCE)
  • 9,000 ft2 warehouse storage
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GMP nucleic acid production

  • 32,000 ft2 (2,973 m2)
  • CleanCap® technology and NTP production for clinical and commercial use
  • On-site quality control lab
  • BARDA Award
  • 32,000 ft2 (2,973 m2)
  • Phase 2 clinical through commercial manufacturing
  • On-site quality control lab

Explore our capabilities

Determined to deliver effective mRNA capping solutions

An essential part of any mRNA compound is the 5’ cap structure, which is critical to the stability, expression, and immunogenicity of an mRNA. We revolutionized mRNA capping strategies with our one-pot CleanCap® capping solutions generating the optimal Cap1 structure with more than 95% efficiency.

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Scalable processes and manufacturing

Maintaining scalability allows your project to keep to the timeline, absorb unexpected surges in demand, and remain aligned with your clinical research goals. Our 118,000 sq ft facility contains multiple specialized manufacturing suites and support labs, ensuring success across a wide variety of scales.

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Analytical support

We have developed extensive in-house capabilities in method development and analytical testing to ensure a high-quality manufacturing process. We work with you to ensure effective method development to meet your objectives. Analytical services available for CleanCap® capping technologies include active moiety quantification, identification, purity, as well as safety and contaminating nucleases for GMP grade products.

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Custom NTPs

We synthesize ultrapure novel nucleotides to meet your specific platform needs. Our expert chemistry team offers custom synthesis of complex modified nucleotides and amidites from the discovery phase to scale up into multi-kilogram quantities. Our experts can guide you to the best solution for your platform needs and provide flexibility to accommodate the stage of your project/program.

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  • Custom NTPs (Custom Chemistry)

Go further with mRNA synthesis services

Since 2012, TriLink has been the industry leader in custom mRNA synthesis for research and clinical applications. Now is your opportunity to leverage TriLink’s mRNA innovations and expertise, including its proprietary CleanCap® technology, CleanScript technology of in vitro transcription (IVT) methods and protocols optimized to reduce dsRNA, standard and custom NTP portfolios, and leading-edge analytical and QC methods.

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Go further with mRNA synthesis services

TriLink’s proprietary mRNA synthesis capabilities include CleanScript in vitro transcription method optimized to decrease dsRNA, scales ranging from milligram to multi-gram, and lengths ranging from a few hundred nucleotides to over 14 kilobases.

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Analytics for mRNA characterization

TriLink’s analytical testing and QC assay capabilities to support mRNA programs include identity, characterization, impurity, and safety testing. Our expert analytical services team also offers construct-specific assays and method development.

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Oligo synthesis

TriLink has been an industry leader in synthesizing high quality oligonucleotides for research, diagnostics, therapeutics, and OEM for more than 20 years. We offer a wide selection of DNA, RNA, modified, and specialty oligonucleotides in scales up to multiple grams.

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Custom RNA oligos

TriLink specializes in synthesizing challenging constructs, such as highly modified gRNA, siRNA, microRNA and aptamers, as well as scaling up to mid-scale quantities, 50 mg to multiple grams. For long RNAs with 100+ bases please see the TriLink mRNA custom synthesis long RNA synthesis by in vitro transcription service.

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Custom DNA oligos

TriLink offers premier quality DNA oligonucleotides in both standard and complicated sequences and modifications, at the scale and purity you need.

Our extensive options for modifications are unparalleled in the industry and include backbone modifications, dye labels and quenchers, modified and inverted bases, linkers and spacers, 5' terminal caps, biotin and other conjugation, dimers and trimers, and more.

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Analytics for oligo synthesis

TriLink has optimized the synthesis and purification of RNA and DNA oligos. Every oligonucleotide manufactured at TriLink undergoes quality control analysis by PAGE, HPLC, and/or MS. Further service options are available including additional purifications and analyses, annealing, aliquoting, and formulation.

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Get to market faster with an effective mRNA capping strategy

TriLink has revolutionized mRNA capping strategies with its one-pot CleanCap® capping solutions generating the optimal Cap1 structure with more than 95% efficiency.

Learn more

Scalable processes and manufacturing

Maintaining scalability allows your project to keep to the timeline, absorb unexpected surges in demand, and remain aligned with your clinical research goals. Our 118,000 sq ft facility contains multiple specialized manufacturing suites and support labs, ensuring success across a wide variety of scales.

Learn more

Find the right analog for your application

TriLink BioTechnologies continues to innovate its growing offering of cap analogs to help meet a variety of applications including CleanCap technology.

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Analytical support

TriLink has developed extensive in-house capabilities in method development and analytical testing to ensure a high-quality manufacturing process. We work with you to ensure effective method development to meet your objectives at each stage of product development. Analytical services available for CleanCap technologies include: active moiety quantification, purity, and identification.

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  • Process Dev/Innovation
  • Analytics

TriLink offers a wide selection of modified nucleoside triphosphates (NTPs) to suit your application needs. We have more than 150 modified NTPs in our ready-to-make portfolio, including aminoallyl, biotin, 2' fluoro, and dye-labeled nucleotides. In addition, we offer specialty modified nucleotides such as 5'-3' bisphosphates, a series of monophosphates, alpha-thiol NTPs, and cap analogs.

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Scale swiftly from the bench to the clinic

Our modified NTP portfolio provides peace of mind when scaling from the bench to the clinic. We operate an ISO 9001:2015 facility, ensuring your mRNA production materials meet reported requirements for identity, purity, and safety. Our stringent quality systems and dedicated team of experts ensure consistency in the product, process, and documentation.

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The first-ever GMP-grade NTPs

As one of the first manufacturers of N1-methylpseudouridine-5’-triphosphate, TriLink provides some of the best NTPs on the market—including the first GMP-grade chemically synthesized NTPs available.

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GMP mRNA manufacturing

Partner with a leading mRNA innovator with 25+ years of proven manufacturing performance. Leverage TriLink's scale up, GMP mRNA manufacturing expertise, and in-house analytical services and method development for mRNA characterization.

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GMP capabilities

TriLink is expanding its mRNA manufacturing capabilities to serve late-phase drug developers. TriLink’s construction of the new 32,000-square-foot, cGMP-grade facility solidifies its commitment to advancing the field as more mRNA-based therapeutics and vaccines enter later-stage clinical trials.

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Plasmid DNA-to-mRNA pathway

To shorten timelines and simplify supply chains, integrate phase-appropriate, high-quality plasmid DNA templates into your mRNA manufacturing process with TriLink’s plasmid DNA-to-mRNA pathway, designed and optimized to support clinical mRNA therapeutic and vaccine programs.

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Process development and scale-up expertise

At TriLink, each mRNA drug substance manufacturing program is supported by a team of mRNA manufacturing experts, providing guidance in program management, process development, scale-up, analytical services, quality, and manufacturing.

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Analytical services for mRNA drug substance

Comprehensive analytical testing and quality control (QC) assays are performed to ensure the purity and integrity of the mRNA drug substance. Our in-house analytics team has extensive experience developing, qualifying, validating, and performing analytical methods.

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  • Plasmid Manufacturing
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Our corporate headquarters

Address

10770 Wateridge Cir Ste 200
San Diego, CA 92121

Phone

Toll Free: (800) 863-6801
(858) 546-0004

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