Inosine-5'-Triphosphate - (N-1020)
ITP, Hypoxanthine
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N-1020
Description
Adenosine deamination is catalyzed by an enzyme called adenosine deaminase acting on RNA (ADAR), and results in the formation of inosine in a process called A-to-I RNA editing. RNA editing plays a crucial role in RNA metabolism, splicing, nuclear export and localization. Inosine 5'-triphosphate (ITP) also functions as an alternative substrate for ATPases and GTPases and has been used to study activation and binding kinetics of nucleoside interaction with various ATPases and GTPases.
Product details
| Catalog No | N-1020 |
|---|---|
| Purity | ≥98% by AX-HPLC |
| Extinction Coefficient | 12,300 Lmol-1cm-1 at 248 nm |
| Molecular Formula | C10H15N4O14P3 (free acid) |
| Molecular Weight | 508.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | ITP, Hypoxanthine |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Inosine |
| Sugar Type(s) | RNA |
| Nucleotide Category | Base Modified RNA |
Technical documents
N-1020 Safety Data Sheet
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Certificate of analysis
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Intellectual property
Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission of Seller. No license under any patent or other intellectual property right of Seller or its licensors is granted or implied by the purchase unless otherwise provided in writing.
TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.
References
- Mortimer, Stefanie A.; Johnson, Jeffrey S.; Weeks, Kevin M. . Quantitative Analysis of RNA Solvent Accessibility by N-Silylation of Guanosineâ€ÂÂ
- Urban, Milan; Joubert, Nicolas; Purse, Byron W.; Hocek, Michal; Kuchta, Robert D. . Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate
- Urban, Milan; Joubert, Nicolas; Hocek, Michal; Alexander, Richard E.; Kuchta, Robert D. . Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase
- ramasamy, s;Sahayasheela, V;Yu, Z;Hidaka, T;Cai, L;Sugiyama, H;Pandian, G; . Chemical Probe-Based Nanopore Sequencing to Selectively Assess the RNA Modification
- Wang, B;Svetlov, D;Artsimovitch, I; . NMPylation and de-NMPylation of SARS-CoV-2 Nsp9 by the NiRAN domain
