Inosine-5'-Triphosphate - (N-1020)
ITP, Hypoxanthine
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N-1020
Description
Adenosine deamination is catalyzed by an enzyme called adenosine deaminase acting on RNA (ADAR), and results in the formation of inosine in a process called A-to-I RNA editing. RNA editing plays a crucial role in RNA metabolism, splicing, nuclear export and localization. Inosine 5'-triphosphate (ITP) also functions as an alternative substrate for ATPases and GTPases and has been used to study activation and binding kinetics of nucleoside interaction with various ATPases and GTPases.
Product details
Catalog No | N-1020 |
---|---|
Purity | ≥98% by AX-HPLC |
Extinction Coefficient | 12,300 Lmol-1cm-1 at 248 nm |
Molecular Formula | C10H15N4O14P3 (free acid) |
Molecular Weight | 508.10 g/mole (free acid) |
Salt Form | Li+ |
Concentration | 100 mM |
Buffer | H2O |
Recommended Storage | -20°C or below |
Other Name(s) | ITP, Hypoxanthine |
Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
Backbone | 5'-Triphosphate |
Base Analog(s) | Inosine |
Sugar Type(s) | RNA |
Nucleotide Category | Base Modified RNA |
Technical documents
N-1020 Safety Data Sheet
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Certificate of analysis
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Intellectual property
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References
- Mortimer, Stefanie A.; Johnson, Jeffrey S.; Weeks, Kevin M. . Quantitative Analysis of RNA Solvent Accessibility by N-Silylation of Guanosineâ€ÂÂ
- Urban, Milan; Joubert, Nicolas; Purse, Byron W.; Hocek, Michal; Kuchta, Robert D. . Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate
- Urban, Milan; Joubert, Nicolas; Hocek, Michal; Alexander, Richard E.; Kuchta, Robert D. . Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase
- ramasamy, s;Sahayasheela, V;Yu, Z;Hidaka, T;Cai, L;Sugiyama, H;Pandian, G; . Chemical Probe-Based Nanopore Sequencing to Selectively Assess the RNA Modification
- Wang, B;Svetlov, D;Artsimovitch, I; . NMPylation and de-NMPylation of SARS-CoV-2 Nsp9 by the NiRAN domain