N6-Methyl-2'-deoxyadenosine-5'-Triphosphate - (N-2025)
N6-Methyl-dATP
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N-2025
Description
N6-methylation of deoxyadenine is a major epigenetic modification in bacteria, and has recently been found at low levels in eukaryotes. The function of this modification is still under investigation, but it may play a role in epigenetic control of gene regulation in specific cell lines.
Product details
| Catalog No | N-2025 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 15,400 Lmol-1cm-1 at 269 nm |
| Molecular Formula | C11H18N5O12P3 (free acid) |
| Molecular Weight | 505.20 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | N6-Methyl-dATP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Adenosine |
| Sugar Type(s) | DNA |
| Nucleotide Category | Base Modified DNA |
Technical documents
N-2025 Safety Data Sheet
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Intellectual property
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References
- Devadoss, Babho; Lee, Irene; Berdis, Anthony J. . Enhancing the "A-rule" of translesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates.
- Marinus, Martin G.; Casadesus, Josep . Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.
- Ratel, David; Ravanat, Jean-Luc; Berger, François; Wion, Didier . N6-methyladenine: the other methylated base of DNA.
- Doshi, Rupak; Chen, Beverly R.; Vibat, Cecile Rose T.; Huang, Norman; Lee, Chang-Wook; Chang, Geoffrey . In vitro nanobody discovery for integral membrane protein targets.
- Dasari, Anvesh; Deodhar, Tejal; Berdis, Anthony J. . A Comparative Analysis of Translesion DNA Synthesis Catalyzed by a High-Fidelity DNA Polymerase.
