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  5. 5' N7-Methylguanosine-triphosphate Cap

5' N7-Methylguanosine-triphosphate Cap - (O-0275)

5' N7-MeGppp, 7mGppp, mRNA Cap
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This modification is available as part of a custom oligonucleotide configuration. Please use OLIGObuilder™ to generate pricing and order or contact us to speak with a customer service representative.

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Product Details

OLIGObuilder Code {N7-MeGppp.}
Other Name(s) 5' N7-MeGppp, 7mGppp, mRNA Cap
Design Requirements 5′ N7-Methylguanosine-triphosphate oligos are not compatible with free amine modifications.
Oligo Modification Type 5' Terminal Caps (Capped Oligos)

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References

Banerjee, A. K. . 5'-terminal cap structure in eucaryotic messenger ribonucleic acids.

Konarska, M. M.; Padgett, R. A.; Sharp, P. A. . Recognition of cap structure in splicing in vitro of mRNA precursors.

Shatkin, A. J. . Capping of eucaryotic mRNAs.

Furuichi, Y.; LaFiandra, A.; Shatkin, A. J. . 5'-Terminal structure and mRNA stability.

Edery, I.; Sonenberg, N. . Cap-dependent RNA splicing in a HeLa nuclear extract.

Kozak, M. . Structural features in eukaryotic mRNAs that modulate the initiation of translation.

Murthy, K. G.; Park, P.; Manley, J. L. . A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates.

Izaurralde, E.; Stepinski, J.; Darzynkiewicz, E.; Mattaj, I. W. . A cap binding protein that may mediate nuclear export of RNA polymerase

Brownlee, G. G.; Fodor, E.; Pritlove, D. C.; Gould, K. G.; Dalluge, J. J. . Solid phase synthesis of 5'-diphosphorylated oligoribonucleotides and their conversion to capped m7Gppp-oligoribonucleotides for use as primers for influenza A virus RNA polymerase in vitro.

Hatta, T.; Ishikawa, M.; Takai, K.; Nakada, S.; Yokota, T.; Hata, T.; Miura, K.; Takaku, H. . Inhibition of influenza virus RNA polymerase by 5'-capped short RNA fragments.

Tado, M.; Abe, T.; Hatta, T.; Ishikawa, M.; Nakada, S.; Yokota, T.; Takaku, H. . Inhibitory effect of modified 5'-capped short RNA fragments on influenza virus RNA polymerase gene expression.

Egloff, Marie-Pierre; Benarroch, Delphine; Selisko, Barbara; Romette, Jean-Louis; Canard, Bruno . An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization.

Hooker, Lisa; Sully, Rachel; Handa, Balraj; Ono, Naomi; Koyano, Hiroshi; Klumpp, Klaus . Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E.

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