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  1. Nucleotide Set 11 items
  2. Nucleotide 50 items
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  6. Inosine 2 items
  1. RNA 3 items
  2. 2'-3'-Dideoxy 1 item
  3. 3'-Azido-2'-Deoxy 1 item
  4. 3'-Amino 1 item
  5. 3'-Deoxy 6 items
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  7. Ara 4 items
  8. 2'-Azido 5 items
  9. 2'-Fluoro 6 items
  10. 2'-O-Methyl 5 items
  11. DNA 3 items
  12. Various 1 item
  13. 3'-O-Methyl 4 items
  1. Phosphodiester 11 items
  2. 5'-Triphosphate 50 items
  1. Aptamers 61 items
  2. Epigenetics/DNA Damage 3 items
  3. In vitro Transcription 1 item
  4. PCR & RT-PCR 2 items

Sugar Modified NTPs

TriLink offers a wide selection sugar modified nucleoside triphosphates. These include 2′-modified as well as 2′, 3′ dideoxynucleoside triphosphates for use in chain termination. These include post-synthetically-modifiable 2′ amino ddNTP for linking to various surfaces or molecules, as well as conjugations to 2′ azido ddNTP for click chemistry applications.

We also offer sugar-modified RNA nucleotides, which impart nuclease resistance to RNA. The molecule retains the A-form duplex structure characteristic of RNA, but modification of the 2′ hydroxyl, which is often crucial to either the binding or the activity of the nuclease enzyme, will offer a level of protection against degradation and other enzymatic events. The most popular sugar modified NTPs are the 2′ O-methyl modified NTPs, followed by the 2′ fluoro-modified NTPs. Both of these modifications increase the melting temperature of a duplex by 1 to 3°C per insertion, depending on which modification is used, the base, and position within the nucleic acid chain. Browse our selection sugar modified NTPs.

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