5' Triphosphate Cap

5’-Triphosphate, 5’-ppp
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This modification is available as part of a custom oligonucleotide configuration. Please use OLIGObuilder™ to generate pricing and order or contact us to speak with a customer service representative.

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Product Details

OLIGObuilder Code {PPP.}
Other Name(s) 5’-Triphosphate, 5’-ppp
Design Requirements 5' Triphosphate oligos are not compatible with free amine modifications.
Oligo Modification Type 5' Terminal Caps (Capped Oligos)


References

Baglioni, C.; Minks, M. A.; Maroney, P. A. . Interferon action may be mediated by activation of a nuclease by pppA2'p5'A2'p5'A.

Clemens, M. J.; Williams, B. R. . Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: a novel oligonucleotide synthesized by interferon-treated L cell extracts.

Kerr, I. M.; Brown, R. E. . pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

Wreschner, D. H.; James, T. C.; Silverman, R. H.; Kerr, I. M. . Ribosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2'p)nA) in interferon-treated cells.

Bartel, D. P.; Szostak, J. W. . Isolation of new ribozymes from a large pool of random sequences [see comment].

Chapman, K. B.; Szostak, J. W. . Isolation of a ribozyme with 5'-5' ligase activity.

Ekland, E. H.; Bartel, D. P. . RNA-catalysed RNA polymerization using nucleoside triphosphates.

Olsen, D. B.; Benseler, F.; Cole, J. L.; Stahlhut, M. W.; Dempski, R. E.; Darke, P. L.; Kuo, L. C. . Elucidation of basic mechanistic and kinetic properties of influenza endonuclease using chemically synthesized RNAs.

Frick, D. N.; Richardson, C. C. . DNA primases.

Hornung, Veit; Ellegast, Jana; Kim, Sarah; Brzózka, Krzysztof; Jung, Andreas; Kato, Hiroki; Poeck, Hendrik; Akira, Shizuo; Conzelmann, Karl-Klaus; Schlee, Martin; Endres, Stefan; Hartmann, Gunther . 5'-Triphosphate RNA is the ligand for RIG-I.

Wang, Yanli; Ludwig, Janos; Schuberth, Christine; Goldeck, Marion; Schlee, Martin; Li, Haitao; Juranek, Stefan; Sheng, Gang; Micura, Ronald; Tuschl, Thomas; Hartmann, Gunther; Patel, Dinshaw J. . Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.

Poeck, Hendrik; Besch, Robert; Maihoefer, Cornelius; Renn, Marcel; Tormo, Damia; Morskaya, Svetlana Shulga; Kirschnek, Susanne; Gaffal, Evelyn; Landsberg, Jennifer; Hellmuth, Johannes; Schmidt, Andreas; Anz, David; Bscheider, Michael; Schwerd, Tobias; Berking, Carola; Bourquin, Carole; Kalinke, Ulrich; Kremmer, Elisabeth; Kato, Hiroki; Akira, Shizuo; Meyers, Rachel; Häcker, Georg; Neuenhahn, Michael; Busch, Dirk; Ruland, Jürgen; Rothenfusser, Simon; Prinz, Marco; Hornung, Veit; Endres, Stefan; Tüting, Thomas; Hartmann, Gunther . 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.

Watts, Jonathan K.; Deleavey, Glen F.; Damha, Masad J. . Chemically modified siRNA: tools and applications.

Schlee, Martin; Roth, Andreas; Hornung, Veit; Hagmann, Cristina Amparo; Wimmenauer, Vera; Barchet, Winfried; Coch, Christoph; Janke, Markus; Mihailovic, Aleksandra; Wardle, Greg; Juranek, Stefan; Kato, Hiroki; Kawai, Taro; Poeck, Hendrik; Fitzgerald, Katherine A.; Takeuchi, Osamu; Akira, Shizuo; Tuschl, Thomas; Latz, Eicke; Ludwig, Janos; Hartmann, Gunther . Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.