Search results for: 'rna'
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Posted in the Zone  on May 25, 2021 , part 1 of this series on optimizing the performance of in vitro  translated (IVT) mRNA using N1-methylpseudouridine (N1mΨ) provided a historical introduction to the development of this chemically modified base. Part 1 focused on a 2015 study and an initial 2018 in vivo  optimization study of N1mΨ-mRNA. This Part 2 blog features a subsequent 2019 publication on in vitro  optimization of N1mΨ-mRNA for future heart gene therapy. Befor...
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Historically, reporter genes  have been delivered as DNA plasmids for transcription into mRNA before translation into a reporter protein. In biological systems, ideal reporter proteins generate highly sensitive signals that are easily measurable. Thus, they are often photoluminescent  (e.g., GFP) or chemiluminescent  (e.g., luciferase).
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The current universe of vaccines can be divided into two main categories, conventional vaccines  and nucleic acid vaccines  ( Blakney et al. ). Conventional vaccines are based on a protein adjuvant, and nucleic acid vaccines can be based on DNA or RNA. For this blog, we will focus on nucleic acid vaccines based on RNA structures and, in particular, self-amplifying RNA vaccines ( Figure 1 ).
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