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  1. mRNA 2 items
  1. Fully substituted with 5-Methoxy-U 1 item
  2. Unmodified bases 1 item
  1. Immunotherapeutics 1 item
  2. Vaccine Development 1 item

Antigen mRNA

mRNAs can be engineered for the quick and cost-effective production of virtually any protein. They can also induce strong immune responses without the risks associated with some live virus vaccines and so are an effective mechanism for delivering vaccine antigens. Whether delivered ex vivo (for example, to dendritic cells) or administered in vivo using a delivery vehicle such as an endosome, exogenous mRNAs can be recognized by pattern recognition receptors in cells and so act as their own adjuvant.

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