Technical assets for the CleanCap® technology
Unleash the full potential of CleanCap® capping technology with our curated learning resources. Explore helpful technical notes, insightful white papers, engaging videos, and educational webinars. Deepen your knowledge, hone your skills, and stay ahead of the curve. Embark on your learning journey today with all resources for our CleanCap technology in one place.
Literature
Technical note: In vivo mRNA expression
In vivo expression of luciferase mRNA synthesized in vitro with co-transcriptional capping via different cap analogs were compared.
Technical note: Enhanced mRNA production
Increasing mRNA yields, without impacting quality attributes, using CleanCap® M6 pulse-feed protocol.
White paper: Economics of mRNA capping strategies
Qualitative findings on the manufacturing costs of three common methods of mRNA capping are presented.
Technical note: saRNA capping methods
Simplifying manufacturing of alphavirus self-amplifying RNA replicons.
Infographic: mRNA capping evolution
Next-generation cap analogs produce Cap-1 structures and allow their incorporation into mRNA in a single in vitro transcription reaction, increasing process efficiency and reducing production time.
Flyer: Increase your mRNA potency
Gain >30% higher protein expression with our latest CleanCap® M6 analog
Case study: A global need meets a large-scale solution
Rapid scale-up manufacturing and analytical testing of CleanCap analogs were achieved to meet timelines and help end the global pandemic.
Poster: Co-transcriptional capping streamlines mRNA manufacturing
CleanCap capping technology is efficient, economical, and high performing.
Video
How does CleanCap® technology work?
Understand co-transcriptional capping vs. post-transcriptional capping and the basics of CleanCap analogs.
How does CleanCap® technology initiate in vitro transcription?
Hear our scientist explain how a CleanCap analog initiates IVT.
What is co-transcriptional capping?
Listen to our Chief Innovation Officer explaining mRNA cap’s functions and co-transcriptional capping.
mRNA caps and CleanCap® technology
Learn about mRNA capping, differences in the mRNA capping methods, and how CleanCap technology can accelerate the development of your mRNA, cell, and gene therapies.
Innovations in CleanCap® technology
Discover our commitment to innovating better versions of CleanCap cap analogs to help our partners come up with better vaccines and treatments.
saRNA capping for vaccine development
Understand considerations for three methods commonly used to cap saRNAs.
Webinars
Innovation in mRNA capping and streamlining process development.
Learn how next-generation capping strategies impact manufacturing costs, timelines, and complexity.
mRNA chemical modifications
Explore multiple strategies to improve mRNA functions, including cap, base, and tail modifications for therapeutic applications.
mRNA capping and manufacturing strategies
Gain insights into the functions and properties of mRNAs, and identify how improved capping strategies can benefit mRNA vaccine development.
