9am - 10:30am PT
In celebration of mRNA Day 2020, TriLink is proud to present back-to-back webinars by two pioneers of the mRNA therapeutic platform: Dr. Katalin Kariko and Dr. Drew Weissman. Dr. Kariko will provide an overview of the history of mRNA therapeutics, while Dr. Weissman will provide his perspective on the future of mRNA medicines.
In a series of seminal manuscripts, Drs. Kariko and Weissman showed that incorporation of modified nucleotides, such as pseudouridine, in mRNAs during in vitro transcription reduces innate immune responses that block mRNA expression. Another critical discovery was that High Performance Liquid Chromatography (HPLC) purification could remove contaminating double stranded RNA from mRNA preparations, further reducing innate immune stimulation. Dr. Kariko is now Senior Vice President at BioNTech RNA Pharmaceuticals, where she works on protein replacement therapies, while Dr. Weissman’s research at the University of Pennsylvania focuses on the development of mRNA-based vaccines.
Join TriLink in celebrating mRNA Day 2020 with two pioneers of mRNA research. A live Q&A session will follow the webinar