Upcoming Events

Treating Viral Infections with mRNA-Encoded Cas13

Venue: Virtual
Date: Sep 30, 2022 - Sep 30, 2022
Title: Treating Viral Infections with mRNA-Encoded Cas13
Date: September 30, 2022
Time: 8 am PT, 11 am ET, 17:00 CET
Duration: 1 Hour

Featured Speakers:
Philip Santangelo, PhD
Professor, Wallace H. Coulter Department of Biomedical Engineering Emory University and Georgia Tech

The potential of gene editing as a therapeutic has come to fruition in the past several years, as clinical data from various studies has shown very positive results. Merging that potential with novel mRNA technologies—which have also demonstrated their value and versatility during the COVID-19 pandemic—could provide scientists and clinicians with an unmatched weapon in the arsenal to fight various diseases. In particular, Cas13 has been used to target RNA viruses in cell culture, but only recently has efficacy in animal models been demonstrated.

This is the third webinar in a series of four, cohosted by GEN and The CRISPR Journal, that is diving deep into the burgeoning world of mRNA research and therapeutics. Our distinguished guest for this event, Dr. Philip Santangelo, will introduce important aspects of how to use mRNA to express Cas13 and use it as an antiviral agent. Additionally, Dr. Santangelo will discuss guide design, screening, the importance of controls, and how to apply this approach in vivo against multiple pathogens.

A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.

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Chemically Modified mRNA as a Biologic: Developing an Analytical Framework for Success

Venue: Virtual
Date: Oct 05, 2022 - Oct 05, 2022
Title: mRNA synthesis from Research to GMP: pathway to successful scale up Date: Oct 5, 2022
Time: 11:30 a.m. EDT (8:30 a.m. PDT)
Duration: 1 Hour

Featured Speaker:
Khaled Yamout
Senior Director Manufacturing & Quality Control, TriLink BioTechnologies

Developing an analytical framework for success using a chemically modified mRNA can be compared with those for traditional biologics. Though much of the regulatory filing requirements can be compared with those for traditional biologics, others are not yet well defined. As such, it’s especially important that control on quality and consistency is maintained to ensure efficacy, purity, and safety. Like traditional biologic products and processes, mRNA-based products require controls on:
  • Quality of the starting material (including cell banking)
  • Consistency of manufacturing processes
  • Identification of critical process parameters
  • Clearance of impurities
  • Establishment of environmental controls to meet safety requirements
  • Thorough characterization of structure, purity, and efficacy

    We will discuss some of these challenges and solutions to support the requirements for characterization of structure, purity, and, efficacy of a well characterized mRNA drug substance

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  • Cell & Gene Meeting on the Mesa

    Venue: Carlsbad, CA, USA
    Date: Oct 11, 2022 - Oct 13, 2022
    The Cell & Gene Meeting on the Mesa is the sector’s foremost annual conference bringing together senior executives and top decision-makers in the industry to advance cutting-edge research into cures. Tackling the commercialization hurdles facing the cell and gene therapy sector today, this meeting covers a wide range of topics from clinical trial design to alternative payment models to scale-up and supply chain platforms for advanced therapies. The in-person partnering meetings will take place October 11-13 in Carlsbad, and the virtual partnering meetings will take place October 18-19 via Zoom..

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    World Vaccine Congress Europe

    Venue: Barcelona, Spain
    Date: Oct 11, 2022 - Oct 14, 2022
    The World Vaccine Congress is an award-winning series of conferences and exhibitions that have grown to become the largest and most established vaccine meeting of its kind across the globe. This event will be delivered as a 2-day complimentary webcast series. Industry leaders and service providers will showcase the power and diversity of mRNA technologies and applications across Discovery, RD, Manufacturing and Delivery.

    Featured Presentation
    Date: tbd, 2022
    Time: tbd a.m. CET
    Title: tbd

    Featured Speaker:

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    Venue: Messe Frankfurt GmbH, Frankfurt am Main, Germany
    Date: Nov 01, 2022 - Nov 03, 2022
    CPHI Frankfurt is the largest pharma event of the year. Join thousands of pharma professionals and industry experts from across the entire supply chain to grow your knowledge and expand your network. Each year CPHI unites more than 100,000 pharmaceutical professionals through exhibitions, conferences and online communities to network, identify business opportunities and expand the global market. Hosting events in Europe, China, Korea, India, Japan, South East Asia and North America, CPHI co-locates with ICSE for contract services, PMEC for machinery, equipment and technology, InnoPack for pharmaceutical packaging, bioLIVE or BioProduction for biopharma and FDF for every aspect of the finished dosage supply chain.

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    Register Now