While mRNA research has been conducted for decades, many therapeutic milestones have been achieved in recent years. Below are some highlights in the history of mRNA therapeutics research and commercialization.
mRNA discovered
mRNA cap discovered
T7 polymerase commercialized
Study shows direct mRNA injection into muscle results in gene expression
Study shows vasopressin mRNA injection into brain corrects disease
Study shows that mRNA stimulates immune responses in mice
TriLink BioTechnologies founded
First mRNA clinical trial for cancer
Study shows that nucleoside-modifying RNA reduces the innate immune response
First mRNA-based CAR-T cell therapy
TriLink establishes mRNA CDMO services
Pre-clinical studies show protective vaccination with mRNA and self-amplifying mRNA (SAM)
Cas9 mRNA used for CRISPR/Cas9 genome editing
TriLink establishes GMP mRNA manufacturing
TriLink expands to new GMP manufacturing facility
Numerous mRNA vaccines deployed against SARS-CoV-2
